AIMC Topic: Microscopy

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High-throughput label-free detection of DNA-to-RNA transcription inhibition using brightfield microscopy and deep neural networks.

Computers in biology and medicine
Drug discovery is in constant evolution and major advances have led to the development of in vitro high-throughput technologies, facilitating the rapid assessment of cellular phenotypes. One such phenotype is immunogenic cell death, which occurs part...

Deep convolutional neural network: a novel approach for the detection of Aspergillus fungi via stereomicroscopy.

Journal of microbiology (Seoul, Korea)
Fungi of the genus Aspergillus are ubiquitously distributed in nature, and some cause invasive aspergillosis (IA) infections in immunosuppressed individuals and contamination in agricultural products. Because microscopic observation and molecular det...

Microscope-Based Automated Quantification of Liver Fibrosis in Mice Using a Deep Learning Algorithm.

Toxicologic pathology
In preclinical studies that involve animal models for hepatic fibrosis, accurate quantification of the fibrosis is of utmost importance. The use of digital image analysis based on deep learning artificial intelligence (AI) algorithms can facilitate a...

Deep learning-based real-time detection of neurons in brain slices for in vitro physiology.

Scientific reports
A common electrophysiology technique used in neuroscience is patch clamp: a method in which a glass pipette electrode facilitates single cell electrical recordings from neurons. Typically, patch clamp is done manually in which an electrophysiologist ...

Towards real-time photorealistic 3D holography with deep neural networks.

Nature
The ability to present three-dimensional (3D) scenes with continuous depth sensation has a profound impact on virtual and augmented reality, human-computer interaction, education and training. Computer-generated holography (CGH) enables high-spatio-a...

Super-Resolution Ultrasound Localization Microscopy Through Deep Learning.

IEEE transactions on medical imaging
Ultrasound localization microscopy has enabled super-resolution vascular imaging through precise localization of individual ultrasound contrast agents (microbubbles) across numerous imaging frames. However, analysis of high-density regions with signi...

Data-efficient and weakly supervised computational pathology on whole-slide images.

Nature biomedical engineering
Deep-learning methods for computational pathology require either manual annotation of gigapixel whole-slide images (WSIs) or large datasets of WSIs with slide-level labels and typically suffer from poor domain adaptation and interpretability. Here we...

Accurate and fast mitotic detection using an anchor-free method based on full-scale connection with recurrent deep layer aggregation in 4D microscopy images.

BMC bioinformatics
BACKGROUND: To effectively detect and investigate various cell-related diseases, it is essential to understand cell behaviour. The ability to detection mitotic cells is a fundamental step in diagnosing cell-related diseases. Convolutional neural netw...