Cancer is a leading cause of death worldwide and a major burden on the healthcare system. Current treatment methods are limited as they have low selectivity, unspecific targeting and increasing multidrug resistance. Therefore, newer modes of therapeu...
Proceedings of the National Academy of Sciences of the United States of America
Aug 20, 2025
AI is now a cornerstone of modern dataset analysis. In many real world applications, practitioners are concerned with controlling specific kinds of errors, rather than minimizing the overall number of errors. For example, biomedical screening assays ...
Cancer remains one of the leading causes of mortality worldwide, where early detection significantly improves patient outcomes and reduces treatment burden. This study investigates the application of Machine Learning (ML) techniques to predict cancer...
DNA replication stress is a hallmark of cancer that is exploited by chemotherapies. Current assays for replication stress have low throughput and poor resolution whilst being unable to map the movement of replication forks genome-wide. We present a n...
Journal of controlled release : official journal of the Controlled Release Society
Aug 18, 2025
Nano-sized drug delivery systems have emerged as a more effective, versatile means for improving cancer treatment. However, the complexity of drug delivery to cancer involves intricate interactions between physiological and physicochemical processes ...
Telomeres, the nucleoprotein structures at the ends of chromosomes, have emerged as critical regulators of cellular aging and key contributors to the pathogenesis of age-related diseases. This comprehensive review examines the evolution of telomere b...
We identified a gene panel comprising 71 glycosyltransferases (GTs) that alter glycan patterns on cancer cells as they become more virulent. When these cancer-pattern GTs (CPGTs) were run through an algorithm trained on The Cancer Genome Atlas, they ...
Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast forma...
BMC medical informatics and decision making
Aug 8, 2025
BACKGROUND: Anti-programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immunotherapy has revolutionized cancer treatment. However, it can cause immune-related adverse events, including acute kidney injury (AKI). Such adverse e...
The integration of mobile health (mHealth) technologies into decentralized clinical trials (DCTs) may represent a paradigm shift in oncology research, offering innovative solutions to longstanding challenges in clinical trial design and execution. mH...
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