AIMC Topic: Glutathione

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Deep machine learning-assisted MOF@COF fluorescence/colorimetric dual-mode intelligent ratiometric sensing platform for sensitive glutathione detection.

Talanta Mar 20, 2025
Glutathione (GSH) levels have been linked to aging and the pathogenesis of various diseases, highlighting the necessity for the development of sensitive analytical methods for GSH to facilitate disease diagnosis and treatment. In this study, we synth...
Limit of Detection Spectrometry, Fluorescence Machine Learning Metal-Organic Frameworks Fluorescence Glutathione Colorimetry
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A hybrid machine learning framework for functional annotation of mitochondrial glutathione transport and metabolism proteins in cancers.

BMC bioinformatics Feb 11, 2025
BACKGROUND: Alterations of metabolism, including changes in mitochondrial metabolism as well as glutathione (GSH) metabolism are a well appreciated hallmark of many cancers. Mitochondrial GSH (mGSH) transport is a poorly characterized aspect of GSH m...
Cell Line, Tumor Biological Transport Mitochondria Humans Molecular Sequence Annotation Glutathione Machine Learning Neoplasms
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Bioinspired Iron Porphyrin Covalent Organic Frameworks-Based Nanozymes Sensor Array: Machine Learning-Assisted Identification and Detection of Thiols.

ACS applied materials & interfaces Dec 12, 2024
Given the crucial role of thiols in maintaining normal physiological functions, it is essential to establish a high-throughput and sensitive analytical method to identify and quantify various thiols accurately. Inspired by the iron porphyrin active c...
Limit of Detection Iron Metal-Organic Frameworks Porphyrins Humans Sulfhydryl Compounds Neural Networks, Computer Glutathione Machine Learning Benzidines Colorimetry Metalloporphyrins
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Predicting lifespan-extending chemical compounds for with machine learning and biologically interpretable features.

Aging Jul 13, 2023
Recently, there has been a growing interest in the development of pharmacological interventions targeting ageing, as well as in the use of machine learning for analysing ageing-related data. In this work, we use machine learning methods to analyse da...
Aging Oxidation-Reduction Glutathione Gene Ontology Machine Learning Algorithms Caenorhabditis elegans Longevity Databases, Pharmaceutical
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Deep learning algorithm reveals two prognostic subtypes in patients with gliomas.

BMC bioinformatics Oct 11, 2022
BACKGROUND: Gliomas are highly complex and heterogeneous tumors, rendering prognosis prediction challenging. The advent of deep learning algorithms and the accessibility of multi-omic data represent a new approach for the identification of survival-s...
Humans Prognosis Deep Learning Gene Expression Regulation, Neoplastic Glioma Glutathione
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DeepCys: Structure-based multiple cysteine function prediction method trained on deep neural network: Case study on domains of unknown functions belonging to COX2 domains.

Proteins Feb 22, 2021
Cysteine (Cys) is the most reactive amino acid participating in a wide range of biological functions. In-silico predictions complement the experiments to meet the need of functional characterization. Multiple Cys function prediction algorithm is scar...
Electron Transport Complex IV Nitroso Compounds Sulfinic Acids Amino Acid Sequence Sulfides Glutathione Disulfides Sulfonic Acids Cysteine Protein Processing, Post-Translational Cations, Divalent Structure-Activity Relationship Protein Structure, Secondary Software Models, Molecular Deep Learning Protein Domains
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Deep learning based prediction of species-specific protein S-glutathionylation sites.

Biochimica et biophysica acta. Proteins and proteomics Mar 29, 2020
As a widespread and reversible post-translational modification of proteins, S-glutathionylation specifically generates the mixed disulfides between cysteine residues and glutathione, which regulates various biological processes including oxidative st...
Animals Deep Learning Mice Protein Processing, Post-Translational Glutathione Species Specificity Cysteine Protein S Humans Algorithms
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Discovery of Small-Molecule Activators for Glucose-6-Phosphate Dehydrogenase (G6PD) Using Machine Learning Approaches.

International journal of molecular sciences Feb 23, 2020
Glucose-6-Phosphate Dehydrogenase (G6PD) is a ubiquitous cytoplasmic enzyme converting glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway (PPP). The G6PD deficiency renders the inability to regenerate glutathione due to lack...
Pentose Phosphate Pathway Glucosephosphate Dehydrogenase Deficiency Drug Evaluation, Preclinical Catalytic Domain Glutathione X-Ray Diffraction Protein Interaction Domains and Motifs Glucosephosphate Dehydrogenase Humans NADP Molecular Docking Simulation Machine Learning Drug Discovery Animals Oxidative Stress Oxidation-Reduction
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Micelle-dominated distribution strategy for non-matrix matched calibration without an internal standard: "Extract-and-shoot" approach for analyzing hydrophilic targets in blood and cell samples.

Analytica chimica acta Dec 17, 2019
The analysis of trace hydrophilic targets in complex aqueous-rich matrices is considerably challenging, generally requiring matrix-matched calibration, internal standard, or time-and-labor-intensive sample preparation. To address this analytical bott...
Chromatography, Reverse-Phase Paraquat Humans Glutathione Micelles Limit of Detection Heating Hydrophobic and Hydrophilic Interactions Diquat Ultrasonic Waves
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Neuroprotective role of 6-Gingerol-rich fraction of Zingiber officinale (Ginger) against acrylonitrile-induced neurotoxicity in male Wistar rats.

Journal of basic and clinical physiology and pharmacology Dec 22, 2018
Background Acrylonitrile (AN) is a neurotoxin that is widely used to manufacture synthetic fibres, plastics and beverage containers. Recently, we reported the ameliorative role of 6-gingerol-rich fraction from Zingiber officinale (Ginger, GRF) on the...
Zingiber officinale Glutathione Transferase Acrylonitrile Cerebral Cortex Fatty Alcohols Rats, Wistar Lipid Peroxidation Tumor Necrosis Factor-alpha Rats Oxidative Stress Superoxide Dismutase Catechols Nitric Oxide Interleukin-6 Antioxidants Inflammation Glutathione Peroxidase Malondialdehyde Animals Plant Extracts Neuroprotection Male Glutathione Catalase
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