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Neural Inhibition

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Divisive gain modulation enables flexible and rapid entrainment in a neocortical microcircuit model.

Journal of neurophysiology
Neocortical circuits exhibit a rich dynamic repertoire, and their ability to achieve entrainment (adjustment of their frequency to match the input frequency) is thought to support many cognitive functions and indicate functional flexibility. Although...

NeuroConstruct-based implementation of structured-light stimulated retinal circuitry.

BMC neuroscience
BACKGROUND: Retinal circuitry provides a fundamental window to neural networks, featuring widely investigated visual phenomena ranging from direction selectivity to fast detection of approaching motion. As the divide between experimental and theoreti...

Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks.

Nature neuroscience
Cortical neurons process information on multiple timescales, and areas important for working memory (WM) contain neurons capable of integrating information over a long timescale. However, the underlying mechanisms for the emergence of neuronal timesc...

Dynamics of a Large-Scale Spiking Neural Network with Quadratic Integrate-and-Fire Neurons.

Neural plasticity
Since the high dimension and complexity of the large-scale spiking neural network, it is difficult to research the network dynamics. In recent decades, the mean-field approximation has been a useful method to reduce the dimension of the network. In t...

Dynamic branching in a neural network model for probabilistic prediction of sequences.

Journal of computational neuroscience
An important function of the brain is to predict which stimulus is likely to occur based on the perceived cues. The present research studied the branching behavior of a computational network model of populations of excitatory and inhibitory neurons, ...

Choice selective inhibition drives stability and competition in decision circuits.

Nature communications
During perceptual decision-making, the firing rates of cortical neurons reflect upcoming choices. Recent work showed that excitatory and inhibitory neurons are equally selective for choice. However, the functional consequences of inhibitory choice se...

Targeting operational regimes of interest in recurrent neural networks.

PLoS computational biology
Neural computations emerge from local recurrent neural circuits or computational units such as cortical columns that comprise hundreds to a few thousand neurons. Continuous progress in connectomics, electrophysiology, and calcium imaging require trac...

Applications of information geometry to spiking neural network activity.

Physical review. E
The space of possible behaviors that complex biological systems may exhibit is unimaginably vast, and these systems often appear to be stochastic, whether due to variable noisy environmental inputs or intrinsically generated chaos. The brain is a pro...

Approximating Nonlinear Functions With Latent Boundaries in Low-Rank Excitatory-Inhibitory Spiking Networks.

Neural computation
Deep feedforward and recurrent neural networks have become successful functional models of the brain, but they neglect obvious biological details such as spikes and Dale's law. Here we argue that these details are crucial in order to understand how r...

Persistent spiking activity in neuromorphic circuits incorporating post-inhibitory rebound excitation.

Journal of neural engineering
. This study introduces a novel approach for integrating the post-inhibitory rebound excitation (PIRE) phenomenon into a neuronal circuit. Excitatory and inhibitory synapses are designed to establish a connection between two hardware neurons, effecti...