AIMC Topic: Peptide Chain Initiation, Translational
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The regulatory landscape of 5' UTRs in translational control during zebrafish embryogenesis.
Developmental cell
Jan 15, 2025
The 5' UTRs of mRNAs are critical for translation regulation during development, but their in vivo regulatory features are poorly characterized. Here, we report the regulatory landscape of 5' UTRs during early zebrafish embryogenesis using a massivel...
CapsNet-TIS: Predicting translation initiation site based on multi-feature fusion and improved capsule network.
Gene
May 22, 2024
Genes are the basic units of protein synthesis in organisms, and accurately identifying the translation initiation site (TIS) of genes is crucial for understanding the regulation, transcription, and translation processes of genes. However, the existi...
Transductive learning as an alternative to translation initiation site identification.
BMC bioinformatics
Feb 2, 2017
BACKGROUND: The correct protein coding region identification is an important and latent problem in the molecular biology field. This problem becomes a challenge due to the lack of deep knowledge about the biological systems and unfamiliarity of conse...
iTIS-PseKNC: Identification of Translation Initiation Site in human genes using pseudo k-tuple nucleotides composition.
Computers in biology and medicine
Sep 25, 2015
Translation is an essential genetic process for understanding the mechanism of gene expression. Due to the large number of protein sequences generated in the post-genomic era, conventional methods are unable to identify Translation Initiation Site (T...
Genomic language models (gLMs) decode bacterial genomes for improved gene prediction and translation initiation site identification.
Briefings in bioinformatics
Jul 2, 2025
Accurate bacterial gene prediction is essential for understanding microbial functions and advancing biotechnology. Traditional methods based on sequence homology and statistical models often struggle with complex genetic variations and novel sequence...
Analysis of RNA translation with a deep learning architecture provides new insight into translation control.
Nucleic acids research
Apr 10, 2025
Accurate annotation of coding regions in RNAs is essential for understanding gene translation. We developed a deep neural network to directly predict and analyze translation initiation and termination sites from RNA sequences. Trained with human tran...
TITER: predicting translation initiation sites by deep learning.
Bioinformatics (Oxford, England)
Jul 15, 2017
MOTIVATION: Translation initiation is a key step in the regulation of gene expression. In addition to the annotated translation initiation sites (TISs), the translation process may also start at multiple alternative TISs (including both AUG and non-A...
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