The red flour beetle (Tribolium castaneum) is a key model organism in developmental biology, genetics, and agricultural research. To address the limited availability of high-quality microscopy data documenting its embryonic morphogenesis, we assemble...
Although contemporary practice in in vitro fertilization (IVF) favors embryo transfer at blastocyst stage, several centres worldwide employ cleavage-stage Day-3 embryo transfers. The advantage of cultures extended to Day-5 and beyond, is to ensure th...
Reproductive biology and endocrinology : RB&E
Nov 27, 2025
BACKGROUND: The application of Artificial Intelligence (AI) to sperm selection during Intracytoplasmic Sperm Injection (ICSI) procedures represents one of the most innovative advances in assisted reproductive technology (ART). Traditional sperm selec...
BACKGROUND: In assisted reproductive technology, evaluating the quality of the embryo is crucial when selecting the most viable embryo for transferring to a woman. Assessment also plays an important role in determining the optimal transfer time, eith...
Systems biology in reproductive medicine
Aug 26, 2025
Early embryo development and competence mechanisms are paramount to ART's success but are still underexplored in human-relevant animal models. Clinical embryo evaluation remains largely based on subjectively evaluated morphological characteristics. I...
In this study, postimplantation human epiblast and amnion development are modeled using a stem cell-based embryoid system. A dataset of 3697 fluorescent images, along with tissue, cavity, and cell masks, is generated from experimental data. A computa...
Embryo development is driven by the spatiotemporal dynamics of complex gene regulatory networks. Uncovering these dynamics requires simultaneous tracking of multiple fluctuating molecular species over time, which exceeds the capabilities of tradition...
Predicting blastocyst formation poses significant challenges in reproductive medicine and critically influences clinical decision-making regarding extended embryo culture. While previous research has primarily focused on determining whether an IVF cy...
Evaluating cumulus-oocyte complex (COC) morphology is commonly used to assess oocyte quality. However, clear guidelines on interpreting COC morphology data are lacking as this evaluation method is subjective. In the present study, individual in vitro...
Accurate embryo assessment on embryonic day 3 of assisted reproductive technology (ART) is crucial for deciding whether to continue the culture until day 5 (blastocyst stage) or opt for earlier transfer or cryopreservation. Prolonged culture often im...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.