BACKGROUND: Small blue round cell tumor (SBRCT) is an umbrella term for several tumor types of completely different cellular origin and differentiation. Members of this tumor group share a common morphological phenotype, which is characterized by sma...
Journal of chemical information and modeling
Sep 3, 2025
The accurate prediction of antiviral peptides (AVPs) plays a crucial role in accelerating the development of peptide-based therapeutics. Despite extensive production of antiviral medications, viral diseases remain a major human health concern. AVPs h...
Mass spectrometry‑based proteomics using isobaric labeling technology has become popular for proteomic quantitation. Existing approaches rely on the mechanism of target-decoy search and false discovery rate control to examine whether a peptide-spectr...
Journal of chemical information and modeling
Aug 25, 2025
Accurate prediction of the peptide-protein interaction (PepPI) is crucial for developing peptide-based therapeutics and vaccines. However, this computational task has traditionally faced significant challenges, such as the scarcity of structure data ...
Skin sensitization is a critical endpoint in toxicology, especially in the context of drug discovery and development process for topical and transdermal treatments. Accurate evaluation of skin sensitization potential is essential to ensure the safety...
Managing inflammation in diabetic chronic wounds remains a major clinical challenge, primarily due to the lack of real-time monitoring techniques. To address this issue, we developed a peptide hydrogel capable of simultaneously monitoring the inflamm...
Journal of chemical information and modeling
Aug 21, 2025
Bioactive peptides are highly specific and have low toxicity, making them a promising treatment option. There are many different types of bioactive peptides, while some types have limited samples (under 500). Methods that can handle limited types of ...
Cancer is a leading cause of death worldwide and a major burden on the healthcare system. Current treatment methods are limited as they have low selectivity, unspecific targeting and increasing multidrug resistance. Therefore, newer modes of therapeu...
In food field, both identification of umami peptides and their sensory evaluation are limited by low efficiency of traditional methods and subjectivity of human-based assessments. To overcome these issues, Umami-Transformer was developed by integrati...
Journal of chemical information and modeling
Aug 12, 2025
Accurate modeling of protein-peptide interactions is essential for understanding fundamental biological processes and designing peptide-based drugs. However, predicting the complex structures of these interactions remains challenging, primarily due t...
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