AIMC Topic: Pluripotent Stem Cells

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Basic fibroblast growth factor is critical to reprogramming buffalo (Bubalus bubalis) primordial germ cells into embryonic germ stem cell-like cells.

Theriogenology
Primordial germ cells (PGCs) are destined to form gametes in vivo, and they can be reprogrammed into pluripotent embryonic germ (EG) cells in vitro. Buffalo PGC have been reported to be reprogrammed into EG-like cells, but the identities of the major...

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System.

Journal of visualized experiments : JoVE
Continued advancement in pluripotent stem cell culture is closing the gap between bench and bedside for using these cells in regenerative medicine, drug discovery and safety testing. In order to produce stem cell derived biopharmaceutics and cells fo...

What insights can spatiotemporal esophageal atlases and deep learning bring to engineering the esophageal mucosa?

Developmental cell
In this issue of Developmental Cell, Yang et al. present an integrated experimental and computational platform that maps the spatiotemporal development of the human esophagus and predicts key signaling pathways governing epithelial differentiation. T...

Artificial Intelligence Supports Automated Characterization of Differentiated Human Pluripotent Stem Cells.

Stem cells (Dayton, Ohio)
Revolutionary advances in AI and deep learning in recent years have resulted in an upsurge of papers exploring applications within the biomedical field. Within stem cell research, promising results have been reported from analyses of microscopy image...

Single-cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs.

Blood
Hematopoietic stem and progenitor cells (HSPCs) develop in distinct waves at various anatomical sites during embryonic development. The in vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates some of these processes; however, i...