AIMC Topic: Prefrontal Cortex

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Random noise promotes slow heterogeneous synaptic dynamics important for robust working memory computation.

Proceedings of the National Academy of Sciences of the United States of America
Recurrent neural networks (RNNs) based on model neurons that communicate via continuous signals have been widely used to study how cortical neural circuits perform cognitive tasks. Training such networks to perform tasks that require information main...

Brain mapping, biomarker identification and using machine learning method for diagnosis of anxiety during emotional face in preschool children.

Brain research bulletin
BACKGROUND: Due to the importance and the consequences of anxiety, the goals of the current study are brain mapping, biomarker identification and the use of an assessment method for diagnosis of anxiety during emotional face in preschool children.

Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model.

Biological psychiatry
BACKGROUND: Identifying neurobiological targets predictive of the molecular neuropathophysiological signature of human opioid use disorder (OUD) could expedite new treatments. OUD is characterized by dysregulated cognition and goal-directed behavior ...

Accuracy deficits during robotic time-constrained reaching are related to altered prefrontal cortex activity in children with cerebral palsy.

Journal of neuroengineering and rehabilitation
BACKGROUND: The prefrontal cortex (PFC) is an important node for action planning in the frontoparietal reaching network but its role in reaching in children with cerebral palsy (CP) is unexplored. This case-control study combines a robotic task with ...

Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction.

Biological psychiatry
BACKGROUND: Opioid addiction is a worldwide public health crisis. In the United States, for example, opioids cause more drug overdose deaths than any other substance. However, opioid addiction treatments have limited efficacy, meaning that additional...

Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS Study.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Clinical studies have proved significant improvements in hand motor function in stroke patients when assisted by robotic devices. However, there were few studies on neural activity changes in the brain during execution. This study aimed to investigat...

Spatially Informed Graph Structure Learning Extracts Insights from Spatial Transcriptomics.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Embeddings derived from cell graphs hold significant potential for exploring spatial transcriptomics (ST) datasets. Nevertheless, existing methodologies rely on a graph structure defined by spatial proximity, which inadequately represents the diversi...

Identifying neuroimaging biomarkers in major depressive disorder using machine learning algorithms and functional near-infrared spectroscopy (fNIRS) during verbal fluency task.

Journal of affective disorders
One of the most prevalent psychiatric disorders is major depressive disorder (MDD), which increases the probability of suicidal ideation or untimely demise. Abnormal frontal hemodynamic changes detected by functional near-infrared spectroscopy (fNIRS...

A recurrent network model of planning explains hippocampal replay and human behavior.

Nature neuroscience
When faced with a novel situation, people often spend substantial periods of time contemplating possible futures. For such planning to be rational, the benefits to behavior must compensate for the time spent thinking. Here, we capture these features ...