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Ribonuclease III

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LBSizeCleav: improved support vector machine (SVM)-based prediction of Dicer cleavage sites using loop/bulge length.

BMC bioinformatics 27887571
BACKGROUND: Dicer is necessary for the process of mature microRNA (miRNA) formation because the Dicer enzyme cleaves pre-miRNA correctly to generate miRNA with correct seed regions. Nonetheless, the mechanism underlying the selection of a Dicer cleav...
Algorithms Base Sequence Bayes Theorem DEAD-box RNA Helicases Humans MicroRNAs Nucleic Acid Conformation Ribonuclease III RNA Precursors Software Support Vector Machine
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Mirnovo: genome-free prediction of microRNAs from small RNA sequencing data and single-cells using decision forests.

Nucleic acids research 29036314
The discovery of microRNAs (miRNAs) remains an important problem, particularly given the growth of high-throughput sequencing, cell sorting and single cell biology. While a large number of miRNAs have already been annotated, there may well be large n...
Algorithms Animals Gene Expression Profiling Genomics High-Throughput Nucleotide Sequencing Humans Machine Learning Mice MicroRNAs Ribonuclease III RNA, Plant RNA, Small Untranslated Sequence Analysis, RNA Single-Cell Analysis Software
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A deep learning framework to predict binding preference of RNA constituents on protein surface.

Nature communications 31666519
Protein-RNA interaction plays important roles in post-transcriptional regulation. However, the task of predicting these interactions given a protein structure is difficult. Here we show that, by leveraging a deep learning model NucleicNet, attributes...
Adenine Animals Area Under Curve Argonaute Proteins Cytosine Deep Learning Gene Knockdown Techniques Guanine Humans Mice Phosphates Protein Binding Ribonuclease III Ribose RNA RNA-Binding Proteins RNA, Small Interfering ROC Curve Uracil
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Investigating Ligand-Mediated Conformational Dynamics of Pre-miR21: A Machine-Learning-Aided Enhanced Sampling Study.

Journal of chemical information and modeling 39526676
MicroRNAs (miRs) are short, noncoding RNA strands that regulate the activity of mRNAs by affecting the repression of protein translation, and their dysregulation has been implicated in several pathologies. miR21 in particular has been implicated in t...
Humans Ligands Machine Learning MicroRNAs Molecular Dynamics Simulation Nucleic Acid Conformation Peptides, Cyclic Ribonuclease III RNA Precursors
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