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SELEX Aptamer Technique

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Constructive Prediction of Potential RNA Aptamers for a Protein Target.

IEEE/ACM transactions on computational biology and bioinformatics 31689200
Aptamers are short single-stranded nucleic acids that bind to target molecules with high affinity and selectivity. Aptamers are generally identified in vitro by performing SELEX (systematic evolution of ligands by exponential enrichment). Complementi...
Aptamers, Nucleotide Computational Biology Decision Trees Protein Binding Protein Structure, Secondary Proteins RNA SELEX Aptamer Technique Support Vector Machine
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Systematic analysis of binding of transcription factors to noncoding variants.

Nature 33505025
Many sequence variants have been linked to complex human traits and diseases, but deciphering their biological functions remains challenging, as most of them reside in noncoding DNA. Here we have systematically assessed the binding of 270 human trans...
Binding Sites Disease Genome, Human Humans Ligands Polymorphism, Single Nucleotide Protein Binding SELEX Aptamer Technique Support Vector Machine Transcription Factors
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A novel artificial intelligence-based approach for identification of deoxynucleotide aptamers.

PLoS computational biology 34343165
The selection of a DNA aptamer through the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method involves multiple binding steps, in which a target and a library of randomized DNA sequences are mixed for selection of a single, nucl...
Algorithms Aptamers, Nucleotide Artificial Intelligence Bayes Theorem Computational Biology Decision Trees Gene Library Humans Ligands Logistic Models Machine Learning Natural Language Processing Protein Binding SELEX Aptamer Technique Support Vector Machine
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High-throughput and computational techniques for aptamer design.

Expert opinion on drug discovery 39390781
INTRODUCTION: Aptamers refer to short ssDNA/RNA sequences that target small molecules, proteins, or cells. Aptamers have significantly advanced diagnostic applications, including biosensors for detecting specific biomarkers, state-of-the-art imaging,...
Aptamers, Nucleotide Biosensing Techniques Computational Biology Drug Design High-Throughput Screening Assays Humans Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation SELEX Aptamer Technique
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