AIMC Topic: SELEX Aptamer Technique

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Aptasensing Technology and Its Potential Applications: Where Do We Stand?

Molecular pharmaceutics Jun 11, 2025
Aptamers, valued for their stability, target affinity, and modifiability, have advanced biosensing, yet key challenges hinder their translation into practical sensing platforms. This work explores the future potential of aptasensing technologies acro...
Humans Animals Nanostructures SELEX Aptamer Technique Aptamers, Nucleotide Biosensing Techniques
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High-throughput and computational techniques for aptamer design.

Expert opinion on drug discovery Oct 10, 2024
INTRODUCTION: Aptamers refer to short ssDNA/RNA sequences that target small molecules, proteins, or cells. Aptamers have significantly advanced diagnostic applications, including biosensors for detecting specific biomarkers, state-of-the-art imaging,...
Drug Design Aptamers, Nucleotide Molecular Docking Simulation Molecular Dynamics Simulation High-Throughput Screening Assays Biosensing Techniques Computational Biology Humans Machine Learning SELEX Aptamer Technique
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A novel artificial intelligence-based approach for identification of deoxynucleotide aptamers.

PLoS computational biology Aug 3, 2021
The selection of a DNA aptamer through the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method involves multiple binding steps, in which a target and a library of randomized DNA sequences are mixed for selection of a single, nucl...
Gene Library Humans SELEX Aptamer Technique Artificial Intelligence Bayes Theorem Computational Biology Ligands Logistic Models Natural Language Processing Support Vector Machine Machine Learning Aptamers, Nucleotide Decision Trees Algorithms Protein Binding
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Systematic analysis of binding of transcription factors to noncoding variants.

Nature Jan 27, 2021
Many sequence variants have been linked to complex human traits and diseases, but deciphering their biological functions remains challenging, as most of them reside in noncoding DNA. Here we have systematically assessed the binding of 270 human trans...
Humans Binding Sites SELEX Aptamer Technique Transcription Factors Support Vector Machine Genome, Human Ligands Disease Protein Binding Polymorphism, Single Nucleotide
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Constructive Prediction of Potential RNA Aptamers for a Protein Target.

IEEE/ACM transactions on computational biology and bioinformatics Nov 4, 2019
Aptamers are short single-stranded nucleic acids that bind to target molecules with high affinity and selectivity. Aptamers are generally identified in vitro by performing SELEX (systematic evolution of ligands by exponential enrichment). Complementi...
SELEX Aptamer Technique Protein Structure, Secondary Support Vector Machine Decision Trees Protein Binding Proteins Aptamers, Nucleotide Computational Biology RNA
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AIoptamer: Artificial Intelligence-Driven Aptamer Optimization Pipeline for Targeted Therapeutics in Healthcare.

Molecular pharmaceutics Jul 7, 2025
Aptamers are short, single-stranded DNA or RNA molecules known for their high specificity and affinity toward target biomolecules, making them powerful tools in drug discovery, diagnostics, and biosensing. However, conventional aptamer selection meth...
Ligands SELEX Aptamer Technique Machine Learning Drug Discovery Deep Learning Humans Aptamers, Nucleotide Artificial Intelligence
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