AIMC Topic: SELEX Aptamer Technique

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High-throughput and computational techniques for aptamer design.

Expert opinion on drug discovery Oct 10, 2024
INTRODUCTION: Aptamers refer to short ssDNA/RNA sequences that target small molecules, proteins, or cells. Aptamers have significantly advanced diagnostic applications, including biosensors for detecting specific biomarkers, state-of-the-art imaging,...
Humans Machine Learning Molecular Docking Simulation Drug Design Aptamers, Nucleotide Biosensing Techniques Computational Biology Molecular Dynamics Simulation High-Throughput Screening Assays SELEX Aptamer Technique
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A novel artificial intelligence-based approach for identification of deoxynucleotide aptamers.

PLoS computational biology Aug 3, 2021
The selection of a DNA aptamer through the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method involves multiple binding steps, in which a target and a library of randomized DNA sequences are mixed for selection of a single, nucl...
Humans Artificial Intelligence Machine Learning Algorithms Aptamers, Nucleotide Protein Binding Computational Biology Logistic Models Support Vector Machine Decision Trees Natural Language Processing Bayes Theorem Ligands Gene Library SELEX Aptamer Technique
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Systematic analysis of binding of transcription factors to noncoding variants.

Nature Jan 27, 2021
Many sequence variants have been linked to complex human traits and diseases, but deciphering their biological functions remains challenging, as most of them reside in noncoding DNA. Here we have systematically assessed the binding of 270 human trans...
Humans Protein Binding Polymorphism, Single Nucleotide Transcription Factors Support Vector Machine Ligands Genome, Human Disease Binding Sites SELEX Aptamer Technique
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Constructive Prediction of Potential RNA Aptamers for a Protein Target.

IEEE/ACM transactions on computational biology and bioinformatics Nov 4, 2019
Aptamers are short single-stranded nucleic acids that bind to target molecules with high affinity and selectivity. Aptamers are generally identified in vitro by performing SELEX (systematic evolution of ligands by exponential enrichment). Complementi...
Aptamers, Nucleotide Protein Binding Computational Biology Support Vector Machine Decision Trees Proteins RNA Protein Structure, Secondary SELEX Aptamer Technique
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