σ serves as an unconventional sigma factor with a distinct mechanism of transcription initiation, which depends on the involvement of a transcription activator. This unique sigma factor σ is indispensable for orchestrating the transcription of genes ...
Computer methods and programs in biomedicine
Jan 6, 2025
The rise in minimally invasive procedures has created a demand for efficient and reliable planning software to predict intra- and post-operative outcomes. Surrogate modelling has shown promise, but challenges remain, particularly in cardiovascular ap...
This study addresses the critical challenge of assessing the quality of groundwater and surface water, which are essential resources for various societal needs. The main contribution of this study is the application of machine learning models for eva...
BACKGROUND: Computed tomography scans are widely used in everyday medical practice due to speed, image reliability, and detectability of a wide range of pathologies. Each scan exposes the patient to a radiation dose, and performing a fast estimation ...
Peptide sequencing via tandem mass spectrometry (MS/MS) is essential in proteomics. Unlike traditional database searches, deep learning excels at de novo peptide sequencing, even for peptides missing from existing databases. Current deep learning mod...
Microsatellite instability (MSI) is a critical phenotype of cancer genomes and an FDA-recognized biomarker that can guide treatment with immune checkpoint inhibitors. Previous work has demonstrated that next-generation sequencing data can be used to ...
Computer methods and programs in biomedicine
Jan 1, 2025
Digital pathology is now a standard component of the pathology workflow, offering numerous benefits such as high-detail whole slide images and the capability for immediate case sharing between hospitals. Recent advances in deep learning-based methods...
peptide sequencing is a valuable technique in mass-spectrometry-based proteomics, as it deduces peptide sequences directly from tandem mass spectra without relying on sequence databases. This database-independent method, however, relies solely on im...
Analyzing microbial samples remains computationally challenging due to their diversity and complexity. The lack of robust de novo protein function prediction methods exacerbates the difficulty in deriving functional insights from these samples. Tradi...
The introduction of quantum computing has transformed the setting of information technology, bringing both unprecedented opportunities and significant challenges. As quantum technologies continue to evolve, addressing their implications for software ...