AIMC Topic: Cell-Free System
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Accelerated enzyme engineering by machine-learning guided cell-free expression.
Nature communications
Jan 20, 2025
Enzyme engineering is limited by the challenge of rapidly generating and using large datasets of sequence-function relationships for predictive design. To address this challenge, we develop a machine learning (ML)-guided platform that integrates cell...
Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dec 28, 2017
The use of essential oils (EOs) is known since long time in traditional medicine and aromatherapy for the management of various oxidative stress-related disorders and has been further increased recently for their neuroprotective and anti-aging potent...
Single-Walled Carbon Nanotube Probes for Protease Characterization Directly in Cell-Free Expression Reactions.
Analytical chemistry
May 27, 2025
Proteins can be rapidly prototyped with cell-free expression (CFE) but in most cases there is a lack of probes or assays to measure their function directly in the cell lysate, thereby limiting the throughput of these screens. Increased throughput is ...
Cell-Free Protein Synthesis as a Method to Rapidly Screen Machine Learning-Generated Protease Variants.
ACS synthetic biology
May 16, 2025
Machine learning (ML) tools have revolutionized protein structure prediction, engineering, and design, but the best ML tool is only as good as the training data it learns from. To obtain high-quality structural or functional data, protein purificatio...
[Cell-Free and Concentrated Ascites Reinfusion Therapy for Malignant Intractable Ascites from Colorectal Cancer].
Gan to kagaku ryoho. Cancer & chemotherapy
Nov 1, 2017
Malignant intractable ascites worsens not only patient symptoms but also their daily activities. It often leads to a patient discontinuing or postponing chemotherapy. In the present study, we introduced cell-free and concentrated ascites reinfusion t...
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