AIMC Topic: Synthetic Biology
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Enabling technology and core theory of synthetic biology.
Science China. Life sciences
Feb 6, 2023
Synthetic biology provides a new paradigm for life science research ("build to learn") and opens the future journey of biotechnology ("build to use"). Here, we discuss advances of various principles and technologies in the mainstream of the enabling ...
Metabolic engineering for sustainability and health.
Trends in biotechnology
Jan 10, 2023
Bio-based production of chemicals and materials has attracted much attention due to the urgent need to establish sustainability and enhance human health. Metabolic engineering (ME) allows purposeful modification of cellular metabolic, regulatory, and...
Perspectives for self-driving labs in synthetic biology.
Current opinion in biotechnology
Jan 3, 2023
Self-driving labs (SDLs) combine fully automated experiments with artificial intelligence (AI) that decides the next set of experiments. Taken to their ultimate expression, SDLs could usher a new paradigm of scientific research, where the world is pr...
A nonlinear neural network based on an analog DNA toehold mediated strand displacement reaction circuit.
Nanoscale
May 5, 2022
The DNA toehold mediated strand displacement reaction is one of the semi-synthetic biology technologies for next-generation computers. In this article, we present a framework for a novel nonlinear neural network based on an engineered biochemical cir...
Microbial chassis engineering drives heterologous production of complex secondary metabolites.
Biotechnology advances
Apr 26, 2022
The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently known secondary metabolites. Heterologous production of secondary metabolite BGCs in suitable chassis facilitates yield improvement and discovery of new-to-nat...
Promoter prediction in nannochloropsis based on densely connected convolutional neural networks.
Methods (San Diego, Calif.)
Mar 31, 2022
Promoter is a key DNA element located near the transcription start site, which regulates gene transcription by binding RNA polymerase. Thus, the identification of promoters is an important research field in synthetic biology. Nannochloropsis is an im...
Machine learning-informed and synthetic biology-enabled semi-continuous algal cultivation to unleash renewable fuel productivity.
Nature communications
Jan 27, 2022
Algal biofuel is regarded as one of the ultimate solutions for renewable energy, but its commercialization is hindered by growth limitations caused by mutual shading and high harvest costs. We overcome these challenges by advancing machine learning t...
Computing within bacteria: Programming of bacterial behavior by means of a plasmid encoding a perceptron neural network.
Bio Systems
Jan 19, 2022
In nature, bacteria exhibit a limited repertoire of behaviors in response to environmental changes. Synthetic biology has now opened up the possibility of programming cells or unicellular organisms in order to enable them to perform certain tasks, wh...
Optimization: Molecular Communication Networks for Viral Disease Analysis Using Deep Leaning Autoencoder.
Computational and mathematical methods in medicine
Dec 13, 2021
Developing new treatments for emerging infectious diseases in infectious and noninfectious diseases has attracted a particular attention. The emergence of viral diseases is expected to accelerate; these data indicate the need for a proactive approach...
Cheetah: A Computational Toolkit for Cybergenetic Control.
ACS synthetic biology
Apr 27, 2021
Advances in microscopy, microfluidics, and optogenetics enable single-cell monitoring and environmental regulation and offer the means to control cellular phenotypes. The development of such systems is challenging and often results in bespoke setups ...
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