Journal of pharmacokinetics and pharmacodynamics
Sep 4, 2025
Pharmacokinetics and toxicological studies how the body reacts to a specific administered substance, such as a drug, toxin, or food. Each substance experiences these four steps: absorption, distribution, metabolism, and excretion, which are the main ...
Emergency toxicology is a complex field requiring rapid and precise decision-making to manage acute poisonings effectively. Toxic exposures are often unpredictable, and the constraints of time and resources often challenge conventional diagnostic and...
Synthetic chemicals are intensively utilized in modern societies, and their mixtures pose significant health and ecological threats. Nontarget screening (NTS) analysis allows for the simultaneous chemical identification and quantitative reporting of ...
BACKGROUND: Poisoning cases involve a wide variety of toxic agents and remain a significant concern for emergency departments. Rapid and accurate intervention is crucial in these cases; however, emergency physicians often face challenges in accessing...
Alternatives to laboratory animals : ATLA
Dec 18, 2024
The first ONTOX Hackathon of the EU Horizon 2020-funded ONTOX project was held on 21-23 April 2024 in Utrecht, The Netherlands (https://ontox-project.eu/hackathon/). This participatory event aimed to collectively advance innovation for human safety t...
The 9th German Pharm-Tox Summit (GPTS) and the 90th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) took place in Munich from March 13-15, 2024. The event brought together over 700 participants fr...
BACKGROUND: The field of toxicology has witnessed substantial advancements in recent years, particularly with the adoption of new approach methodologies (NAMs) to understand and predict chemical toxicity. Class-based methods such as clustering and cl...
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Jun 8, 2024
This Special Issue contains articles on applications of various new approach methodologies (NAMs) in the field of toxicology and risk assessment. These NAMs include in vitro high-throughput screening, quantitative structure-activity relationship (QSA...
Both because of the shortcomings of existing risk assessment methodologies, as well as newly available tools to predict hazard and risk with machine learning approaches, there has been an emerging emphasis on probabilistic risk assessment. Increasing...
Expert opinion on drug metabolism & toxicology
Dec 29, 2023
INTRODUCTION: The application of Artificial Intelligence (AI) to predictive toxicology is rapidly increasing, particularly aiming to develop non-testing methods that effectively address ethical concerns and reduce economic costs. In this context, Dev...
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