AIMC Topic: Transcriptome

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A machine learning approach for the identification of key markers involved in brain development from single-cell transcriptomic data.

BMC genomics
BACKGROUND: The ability to sequence the transcriptomes of single cells using single-cell RNA-seq sequencing technologies presents a shift in the scientific paradigm where scientists, now, are able to concurrently investigate the complex biology of a ...

On the inconsistency of ℓ -penalised sparse precision matrix estimation.

BMC bioinformatics
BACKGROUND: Various ℓ -penalised estimation methods such as graphical lasso and CLIME are widely used for sparse precision matrix estimation and learning of undirected network structure from data. Many of these methods have been shown to be consisten...

Transcriptome assists prognosis of disease severity in respiratory syncytial virus infected infants.

Scientific reports
Respiratory syncytial virus (RSV) causes infections that range from common cold to severe lower respiratory tract infection requiring high-level medical care. Prediction of the course of disease in individual patients remains challenging at the first...

Comprehensive analysis of epigenetically regulated genes in anergic T cells.

Cellular immunology
T cell anergy is one of the important mechanisms for immune tolerance. The results of many studies investigating the mechanism for T cell anergy induction have revealed that the expression of several genes was up-regulated in anergic T cells. It has ...

Consistent quantitative gene product expression: #3. Invariance with age.

Cytometry. Part A : the journal of the International Society for Analytical Cytology
The quantitative expression of cell surface antigens and light scattering properties of five cellular reference populations in stressed bone marrow specimens were compared between pediatric and adult patients treated for acute myeloid leukemia (AML)....

Consistent quantitative gene product expression: #2. Antigen intensities on bone marrow cells are invariant between individuals.

Cytometry. Part A : the journal of the International Society for Analytical Cytology
Five reference populations in bone marrow specimens were identified by flow cytometry using specific combinations of reagents in order define the variation of gene product expression intensities both within and between individuals. Mature lymphocytes...

Transcriptomic alterations in Sitophilus zeamais in response to allyl isothiocyanate fumigation.

Pesticide biochemistry and physiology
To study the fumigation mechanisms of Allyl isothiocyanate (AITC) a promising biorational alternative to present fumigants (phosphine and methyl bromide), and provide theoretical basis for its further development in the control of stored grain pests,...

Detecting Essential Proteins Based on Network Topology, Gene Expression Data, and Gene Ontology Information.

IEEE/ACM transactions on computational biology and bioinformatics
The identification of essential proteins in protein-protein interaction (PPI) networks is of great significance for understanding cellular processes. With the increasing availability of large-scale PPI data, numerous centrality measures based on netw...

Inferring Unknown Biological Function by Integration of GO Annotations and Gene Expression Data.

IEEE/ACM transactions on computational biology and bioinformatics
Characterizing genes with semantic information is an important process regarding the description of gene products. In spite that complete genomes of many organisms have been already sequenced, the biological functions of all of their genes are still ...

Symbiont modulates expression of specific gene categories in Angomonas deanei.

Memorias do Instituto Oswaldo Cruz
Trypanosomatids are parasites that cause disease in humans, animals, and plants. Most are non-pathogenic and some harbor a symbiotic bacterium. Endosymbiosis is part of the evolutionary process of vital cell functions such as respiration and photosyn...