Alzheimer's & dementia : the journal of the Alzheimer's Association
Jun 11, 2024
INTRODUCTION: Most people with Alzheimer's disease and related dementia (ADRD) also suffer from two or more chronic conditions, known as multiple chronic conditions (MCC). While many studies have investigated the MCC patterns, few studies have consid...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Oct 14, 2023
INTRODUCTION: A wide range of modifiable risk factors for dementia have been identified. Considerable debate remains about these risk factors, possible interactions between them or with genetic risk, and causality, and how they can help in clinical t...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Sep 28, 2023
INTRODUCTION: Cranial computed tomography (CT) is an affordable and widely available imaging modality that is used to assess structural abnormalities, but not to quantify neurodegeneration. Previously we developed a deep-learning-based model that pro...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Aug 28, 2023
Artificial intelligence (AI) and machine learning (ML) approaches are increasingly being used in dementia research. However, several methodological challenges exist that may limit the insights we can obtain from high-dimensional data and our ability ...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Aug 22, 2023
Genetics and omics studies of Alzheimer's disease and other dementia subtypes enhance our understanding of underlying mechanisms and pathways that can be targeted. We identified key remaining challenges: First, can we enhance genetic studies to addre...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Aug 16, 2023
Drug discovery and clinical trial design for dementia have historically been challenging. In part these challenges have arisen from patient heterogeneity, length of disease course, and the tractability of a target for the brain. Applying big data ana...
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jul 26, 2023
INTRODUCTION: The use of applied modeling in dementia risk prediction, diagnosis, and prognostics will have substantial public health benefits, particularly as "deep phenotyping" cohorts with multi-omics health data become available.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Jul 6, 2023
BACKGROUND: Identifying genetic patterns that contribute to Alzheimer's disease (AD) is important not only for pre-symptomatic risk assessment but also for building personalized therapeutic strategies.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Feb 3, 2023
INTRODUCTION: Machine learning research into automated dementia diagnosis is becoming increasingly popular but so far has had limited clinical impact. A key challenge is building robust and generalizable models that generate decisions that can be rel...