Journal of pediatric gastroenterology and nutrition
May 8, 2025
OBJECTIVE: Colonic manometry (CM) involves measurement of colonic neuromuscular activity and administration of a stimulant laxative, most commonly bisacodyl, which is part of the study protocol. Glycerin is another laxative used in the treatment of c...
Journal of pediatric gastroenterology and nutrition
May 8, 2025
OBJECTIVES: This study evaluates the effectiveness of three widely used large language models (LLMs)-ChatGPT-4, Copilot, and Gemini-in providing accurate, reliable, and understandable answers to frequently asked questions about pediatric dysphagia.
Journal of pediatric gastroenterology and nutrition
Aug 9, 2024
OBJECTIVES: Classical Hirschsprung disease (HD) is defined by the absence of ganglion cells in the rectosigmoid colon. The diagnosis is made from rectal biopsy, which reveals the aganglionosis and the presence of cholinergic hyperinnervation. However...
Journal of pediatric gastroenterology and nutrition
Dec 27, 2023
OBJECTIVES: Eosinophil-derived neurotoxin (EDN) is a viable marker of eosinophilic esophagitis (EoE) disease activity. We studied the utility of measuring EDN from esophageal epithelial brushings for diagnosing EoE, focusing on two scenarios: (1) cas...
Journal of pediatric gastroenterology and nutrition
Dec 11, 2023
BACKGROUND: Food protein-induced allergic proctocolitis (FPIAP) is a nonimmunoglobulin (IgE)-mediated food hypersensitivity and the exact mechanisms that cause FPIAP are unknown. Chemokines play crucial roles in the development of allergic diseases.
Journal of pediatric gastroenterology and nutrition
Dec 10, 2023
OBJECTIVES: While higher infliximab (IFX) trough concentrations (TCs) are associated with better outcomes in patients with inflammatory bowel disease (IBD), they could pose a risk for adverse events (AEs), including IFX-induced skin lesions. Therefor...
Journal of pediatric gastroenterology and nutrition
Dec 5, 2023
OBJECTIVES: Antibodies to infliximab (ATIs) are associated with loss of response in children with inflammatory bowel disease (IBD). We aimed to describe the effectiveness of strategies for treatment modification following ATI development in pediatric...
Journal of pediatric gastroenterology and nutrition
Jun 1, 2021
OBJECTIVES: Striking histopathological overlap between distinct but related conditions poses a disease diagnostic challenge. There is a major clinical need to develop computational methods enabling clinicians to translate heterogeneous biomedical ima...