AIMC Topic: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine

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An integrated machine learning approach delineates an entropic expansion mechanism for the binding of a small molecule to α-synuclein.

eLife Dec 18, 2024
The mis-folding and aggregation of intrinsically disordered proteins (IDPs) such as α-synuclein (αS) underlie the pathogenesis of various neurodegenerative disorders. However, targeting αS with small molecules faces challenges due to the lack of defi...
Humans Machine Learning Protein Binding alpha-Synuclein Intrinsically Disordered Proteins Protein Conformation Thermodynamics Entropy 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
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DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining.

RNA biology Apr 7, 2017
Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are criti...
Humans Software Disease Progression MicroRNAs RNA, Long Noncoding Knowledge Bases Data Mining Alzheimer Disease Gene Ontology Dictionaries as Topic 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
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