AIMC Topic: Algorithms

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[Prediction of depression symptoms in seniors and analysis of influencing factors based on explainable machine learning].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
This study aims to construct a machine learning model to predict depression symptoms in the elderly and analyze the key influencing factors of depression in the elderly using the shapley additive interpretation (SHAP) method. Based on entries from ...

The Harms of Class Imbalance Corrections for Machine Learning Based Prediction Models: A Simulation Study.

Statistics in medicine
INTRODUCTION: Risk prediction models are increasingly used in healthcare to aid in clinical decision-making. In most clinical contexts, model calibration (i.e., assessing the reliability of risk estimates) is critical. Data available for model develo...

The accuracy of automated facial landmarking - a comparative study between Cliniface software and patch-based Convoluted Neural Network algorithm.

European journal of orthodontics
BACKGROUND: Automatic landmarking software packages simplify the analysis of the 3D facial images. Their main deficiency is the limited accuracy of detecting landmarks for routine clinical applications. Cliniface is readily available open-access soft...

Diagnosis of Alzheimer's disease using FusionNet with improved secretary bird optimization algorithm for optimal MK-SVM based on imaging genetic data.

Cerebral cortex (New York, N.Y. : 1991)
Alzheimer's disease is an irreversible central neurodegenerative disease, and early diagnosis of Alzheimer's disease is beneficial for its prevention and early intervention treatment. In this study, we propose a novel framework, FusionNet-ISBOA-MK-SV...

PNL: a software to build polygenic risk scores using a super learner approach based on PairNet, a Convolutional Neural Network.

Bioinformatics (Oxford, England)
SUMMARY: Polygenic risk scores (PRSs) hold promise for early disease diagnosis and personalized treatment, but their overall discriminative power remains limited for many diseases in the general population. As a result, numerous novel PRS modeling te...

MolFCL: predicting molecular properties through chemistry-guided contrastive and prompt learning.

Bioinformatics (Oxford, England)
MOTIVATION: Accurately identifying and predicting molecular properties is a crucial task in molecular machine learning, and the key lies in how to extract effective molecular representations. Contrastive learning opens new avenues for representation ...

Robustly interrogating machine learning-based scoring functions: what are they learning?

Bioinformatics (Oxford, England)
MOTIVATION: Machine learning-based scoring functions (MLBSFs) have been found to exhibit inconsistent performance on different benchmarks and be prone to learning dataset bias. For the field to develop MLBSFs that learn a generalizable understanding ...

MEGA-GO: functions prediction of diverse protein sequence length using Multi-scalE Graph Adaptive neural network.

Bioinformatics (Oxford, England)
MOTIVATION: The increasing accessibility of large-scale protein sequences through advanced sequencing technologies has necessitated the development of efficient and accurate methods for predicting protein function. Computational prediction models hav...

ESCARGOT: an AI agent leveraging large language models, dynamic graph of thoughts, and biomedical knowledge graphs for enhanced reasoning.

Bioinformatics (Oxford, England)
MOTIVATION: LLMs like GPT-4, despite their advancements, often produce hallucinations and struggle with integrating external knowledge effectively. While Retrieval-Augmented Generation (RAG) attempts to address this by incorporating external informat...

A comprehensive graph neural network method for predicting triplet motifs in disease-drug-gene interactions.

Bioinformatics (Oxford, England)
MOTIVATION: The drug-disease, gene-disease, and drug-gene relationships, as high-frequency edge types, describe complex biological processes within the biomedical knowledge graph. The structural patterns formed by these three edges are the graph moti...