AIMC Topic: Amyloid Precursor Protein Secretases

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[Effects of long non-coding RNA RP1-90L14.1 on the biological behaviors of cancer prostate LNCaP cells and its regulating mechanisms].

Zhonghua nan ke xue = National journal of andrology Mar 1, 2019
OBJECTIVE: To investigate the effects of long non-coding RNA RP1-90L14.1 on the proliferation, migration and invasion of prostate cancer LNCaP cells and the expressions of GRIN2A and BACE2.
Humans Male Cell Line, Tumor Gene Expression Regulation, Neoplastic Cell Proliferation Cell Movement Neoplasm Invasiveness RNA, Long Noncoding Prostatic Neoplasms Transfection Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Receptors, N-Methyl-D-Aspartate
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A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.

Current pharmaceutical biotechnology Jan 1, 2017
BACKGROUND: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.
Humans Blood-Brain Barrier Drug Delivery Systems Animals Nanoparticles Rats Mice, Nude Drug Carriers RNA, Small Interfering Neurons Alzheimer Disease Permeability Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Molecular Targeted Therapy PC12 Cells Gene Knockdown Techniques
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Discrimination of Active and Weakly Active Human BACE1 Inhibitors Using Self-Organizing Map and Support Vector Machine.

Combinatorial chemistry & high throughput screening Jan 1, 2016
β-secretase (BACE1) is an aspartyl protease, which is considered as a novel vital target in Alzheimer`s disease therapy. We collected a data set of 294 BACE1 inhibitors, and built six classification models to discriminate active and weakly active inh...
Humans Sensitivity and Specificity Drug Design Support Vector Machine Alzheimer Disease Enzyme Inhibitors Linear Models Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases
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