AIMC Topic: Animal Testing Alternatives
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Artificial intelligence in preclinical research: enhancing digital twins and organ-on-chip to reduce animal testing.
Drug discovery today
Apr 17, 2025
Artificial intelligence (AI) is reshaping preclinical drug research offering innovative alternatives to traditional animal testing. Advanced techniques, including machine learning (ML), deep learning (DL), AI-powered digital twins (DTs), and AI-enhan...
Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research.
Biotechnology advances
Apr 1, 2025
Human settlements on the Moon, crewed missions to Mars and space tourism will become a reality in the next few decades. Human presence in space, especially for extended periods of time, will therefore steeply increase. However, despite more than 60 y...
Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology - A Potential Driver for Reducing/Replacing Laboratory Animals in the Future.
Alternatives to laboratory animals : ATLA
Dec 18, 2024
The first ONTOX Hackathon of the EU Horizon 2020-funded ONTOX project was held on 21-23 April 2024 in Utrecht, The Netherlands (https://ontox-project.eu/hackathon/). This participatory event aimed to collectively advance innovation for human safety t...
Hybrid non-animal modeling: A mechanistic approach to predict chemical hepatotoxicity.
Journal of hazardous materials
Apr 12, 2024
Developing mechanistic non-animal testing methods based on the adverse outcome pathway (AOP) framework must incorporate molecular and cellular key events associated with target toxicity. Using data from an in vitro assay and chemical structures, we a...
The probable future of toxicology - probabilistic risk assessment.
ALTEX
Jan 12, 2024
Both because of the shortcomings of existing risk assessment methodologies, as well as newly available tools to predict hazard and risk with machine learning approaches, there has been an emerging emphasis on probabilistic risk assessment. Increasing...
Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi.
Archives of toxicology
May 3, 2022
Alternative methods to animal use in toxicology are evolving with new advanced tools and multilevel approaches, to answer from one side to 3Rs requirements, and on the other side offering relevant and valid tests for drugs and chemicals, considering ...
RespiraTox - Development of a QSAR model to predict human respiratory irritants.
Regulatory toxicology and pharmacology : RTP
Nov 30, 2021
Respiratory irritation is an important human health endpoint in chemical risk assessment. There are two established modes of action of respiratory irritation, 1) sensory irritation mediated by the interaction with sensory neurons, potentially stimula...
Development of quantitative model of a local lymph node assay for evaluating skin sensitization potency applying machine learning CatBoost.
Regulatory toxicology and pharmacology : RTP
Jul 24, 2021
The estimated concentrations for a stimulation index of 3 (EC3) in murine local lymph node assay (LLNA) is an important quantitative value for determining the strength of skin sensitization to chemicals, including cosmetic ingredients. However, anima...
Curated Data In - Trustworthy Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing.
Alternatives to laboratory animals : ATLA
Jul 7, 2021
New Approach Methodologies (NAMs) that employ artificial intelligence (AI) for predicting adverse effects of chemicals have generated optimistic expectations as alternatives to animal testing. However, the major underappreciated challenge in developi...
Safer chemicals using less animals: kick-off of the European ONTOX project.
Toxicology
Jun 30, 2021
The 3Rs concept, calling for replacement, reduction and refinement of animal experimentation, is receiving increasing attention around the world, and has found its way to legislation, in particular in the European Union. This is aligned by continuing...
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