Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development. Traditionally, humanization is manual, laborious, and requires expert k...
The Journal of the Acoustical Society of America
Jan 1, 2022
Bearded seals vocalizations are often analyzed manually or by using automatic detections that are manually validated. In this work, an automatic detection and classification system (DCS) based on convolutional neural networks (CNNs) is proposed. Bear...
BACKGROUND: Inspection of livestock farms using surveillance cameras is emerging as a means of early detection of transboundary animal disease such as African swine fever (ASF). Object tracking, a developing technology derived from object detection a...
Journal of computational biology : a journal of computational molecular cell biology
Jan 1, 2022
We propose GRNUlar, a novel deep learning framework for supervised learning of gene regulatory networks (GRNs) from single-cell RNA-Sequencing (scRNA-Seq) data. Our framework incorporates two intertwined models. First, we leverage the expressive abil...
OBJECTIVE: The application of robots in the field of pedicle screw placement has achieved great success. However, decompressive laminectomy, a step that is just as critical as pedicle screw placement, does not have a mature robot-assisted system. To ...
Nonlinear dynamics, psychology, and life sciences
Jan 1, 2022
We describe the locomotion of Caenorhabditis elegans (C. elegans) using nonlinear dynamics. C. elegans is a commonly studied model organism based on ease of maintenance and simple neurological structure. In contrast to traditional microscopic techniq...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
The development of vaccines for the treatment of COVID-19 is paving the way for new hope. Despite this, the risk of the virus mutating into a vaccine-resistant variant still persists. As a result, the demand of efficacious drugs to treat COVID-19 is ...
The failure of animal studies to translate to effective clinical therapeutics has driven efforts to identify underlying cause and develop solutions that improve the reproducibility and translatability of preclinical research. Common issues revolve ar...
MOTIVATION: In silico identification of linear B-cell epitopes represents an important step in the development of diagnostic tests and vaccine candidates, by providing potential high-probability targets for experimental investigation. Current predict...
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