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Anti-Infective Agents

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Variations of the chemical components and biological activities of Thymus capitatus essential oil from three regions in Palestine.

Scientific reports
Thymus capitatus is a widely utilized medicinal plant in Palestine. The main goal of this study was to assess the phytochemical content of T. capitatus essential oils (EOs) from three Palestinian regions using hydro-distillation. Furthermore, the EO ...

In vitro antimicrobial and anticancer potentials of green synthesized luminescent carbon quantum dots derived from artichoke leaves.

Scientific reports
Naturally derived carbon quantum dots (CQDs) are novel carbon-based nanomaterials with excellent traits. It is highly demanded to develop CQDs from biowaste that have excellent photostability, a simple synthesis approach, and an appealing output so t...

Facile phyto-mediated synthesis of ternary CuO/MnO/ZnO nanocomposite using Nigella Sativa seeds extract: characterization,antimicrobial, and biomedical evaluations.

Scientific reports
The phyto-synthesis of ternary CuO/ MnO/ZnO nanocomposite was achieved by the utilization of an eco-friendly, straightforward approach that involved the extract of Nigella sativa seeds. Our ternary nanocomposite appears to include equal amounts of Cu...

Bioactivity and chemical screening of endophytic fungi associated with seaweeds Gracilaria sp. and Sargassum sp. of the Bay of Bengal, Bangladesh.

Scientific reports
This study explored the great potential of endophytic fungi associated with red seaweed Gracilaria sp. and brown seaweed Sargassum sp. of the Bay of Bengal, Bangladesh, for the first time. Endophytic fungi were identified taxonomically by morphologic...

Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights.

Microbial cell factories
BACKGROUND: The rising danger of antibiotic resistance and the increasing burden of cancer worldwide have highlighted the necessity for a constant supply of new antimicrobial drugs and anticancer therapies. Endophytic fungi, recognized as a rich supp...

A machine learning method for predicting molecular antimicrobial activity.

Scientific reports
In response to the increasing concern over antibiotic resistance and the limitations of traditional methods in antibiotic discovery, we introduce a machine learning-based method named MFAGCN. This method predicts the antimicrobial efficacy of molecul...

Predicting Antimicrobial Class Specificity of Small Molecules Using Machine Learning.

Journal of chemical information and modeling
While the useful armory of antibiotic drugs is continually depleted due to the emergence of drug-resistant pathogens, the development of novel therapeutics has also slowed down. In the era of advanced computational methods, approaches like machine le...

Artificial Intuition and accelerating the process of antimicrobial drug discovery.

Computers in biology and medicine
New drug development is a very challenging, expensive, and usually time-consuming process. This issue is very important with regard to antimicrobials, which are affected by the global issue of the development and spread of resistance. This framework ...

Biofilm-mediated infections; novel therapeutic approaches and harnessing artificial intelligence for early detection and treatment of biofilm-associated infections.

Microbial pathogenesis
A biofilm is a group of bacteria that have self-produced a matrix and are grouped together in a dense population. By resisting the host's immune system's phagocytosis process and attacking with anti-microbial chemicals such as reactive oxygen and nit...

Strategies in using artificial intelligence to combat antimicrobial resistance.

Recenti progressi in medicina
Infectious diseases caused by pathogens resistant to antimicrobial treatments, defined as antimicrobial resistance (AMR), are a serious global health crisis, considered among the main threats to global public health according to the World Health Orga...