Proceedings of the National Academy of Sciences of the United States of America
Jun 4, 2025
Characterizing the conformational ensemble of biomolecular systems is key to understand their functions. Cryoelectron microscopy (cryo-EM) captures two-dimensional snapshots of biomolecular ensembles, giving in principle access to thermodynamics. How...
For analysis of crystallization, the solubility of drug in solvents should be correlated to input parameters. In this investigation, the solubility of salicylic acid as drug model in a variety of solvents is predicted through the utilization of multi...
By employing machine-learning models, this study utilizes agronomical and molecular features to predict powdery mildew disease resistance in Barley (Hordeum Vulgare L). A 130-line F8-F9 barley population caused Badia and Kavir to grow at the Gonbad K...
Determining by means of palaeography the chronology of ancient handwritten manuscripts such as the Dead Sea Scrolls is essential for reconstructing the evolution of ideas, but there is an almost complete lack of date-bearing manuscripts. To overcome ...
BACKGROUND: Gene regulatory network modeling is a complex structure learning problem that involves both observational data analysis and experimental interventions. Bayesian causal discovery provides a principled framework for modeling observational d...
This study develops and evaluates advanced hybrid machine learning models-ADA-ARD (AdaBoost on ARD Regression), ADA-BRR (AdaBoost on Bayesian Ridge Regression), and ADA-GPR (AdaBoost on Gaussian Process Regression)-optimized via the Black Widow Optim...
Machine learning techniques offer promising avenues for enhancing animal breeding programs by leveraging genomic and phenotypic data to predict valuable traits accurately. In this study, we evaluated seven machine learning algorithms viz., K-nearest ...
PURPOSE: Lymph node metastasis (LNM) significantly affects prognosis and treatment strategies in non-small cell lung cancer (NSCLC). Current diagnostic methods, including imaging and histopathology, have limited sensitivity and specificity. This stud...
Prostate cancer (PCa) is a major, and increasingly global, health concern with current screening and diagnostic tools' severe limitations causing unnecessary, invasive biopsy procedures. While gas chromatography-mass spectrometry (GC-MS) has been use...
BACKGROUND: The global malaria burden is characterized by economic, geographical, and climatic disparities, especially in sub-Saharan Africa (SSA). Moreover, meteorological factors have become increasingly important to understand the malaria burden i...
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