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Biotechnology

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Machine learning-informed and synthetic biology-enabled semi-continuous algal cultivation to unleash renewable fuel productivity.

Nature communications
Algal biofuel is regarded as one of the ultimate solutions for renewable energy, but its commercialization is hindered by growth limitations caused by mutual shading and high harvest costs. We overcome these challenges by advancing machine learning t...

Computing within bacteria: Programming of bacterial behavior by means of a plasmid encoding a perceptron neural network.

Bio Systems
In nature, bacteria exhibit a limited repertoire of behaviors in response to environmental changes. Synthetic biology has now opened up the possibility of programming cells or unicellular organisms in order to enable them to perform certain tasks, wh...

Forty years of directed evolution and its continuously evolving technology toolbox: A review of the patent landscape.

Biotechnology and bioengineering
Generating functional protein variants with novel or improved characteristics has been a goal of the biotechnology industry and life sciences, for decades. Rational design and directed evolution are two major pathways to achieve the desired ends. Whi...

The future of Artificial Intelligence for the BioTech Big Data landscape.

Current opinion in biotechnology
Recent Industry 4.0 advancements are making available massive amounts of data for the development of innovative BioTech solutions. However, several challenges need to be overcome to correctly use data and novel, non-pharma technologies to greatly spe...

Machine learning to navigate fitness landscapes for protein engineering.

Current opinion in biotechnology
Machine learning (ML) is revolutionizing our ability to understand and predict the complex relationships between protein sequence, structure, and function. Predictive sequence-function models are enabling protein engineers to efficiently search the s...

Logic-enabled textiles.

Proceedings of the National Academy of Sciences of the United States of America
Textiles hold great promise as a soft yet durable material for building comfortable robotic wearables and assistive devices at low cost. Nevertheless, the development of smart wearables composed entirely of textiles has been hindered by the lack of a...

Continuous biomanufacturing with microbes - upstream progresses and challenges.

Current opinion in biotechnology
Current biomanufacturing facilities are mainly built for batch or fed-batch operations, which are subject to low productivities and do not achieve the great bioconversion potential of the rewired cells generated via modern biotechnology. Continuous b...

Omics Data and Data Representations for Deep Learning-Based Predictive Modeling.

International journal of molecular sciences
Medical discoveries mainly depend on the capability to process and analyze biological datasets, which inundate the scientific community and are still expanding as the cost of next-generation sequencing technologies is decreasing. Deep learning (DL) i...

Review on machine learning-based bioprocess optimization, monitoring, and control systems.

Bioresource technology
Machine Learning is quickly becoming an impending game changer for transforming big data thrust from the bioprocessing industry into actionable output. However, the complex data set from bioprocess, lagging cyber-integrated sensor system, and issues ...

Robotics-assisted, organic agricultural-biotechnology based environment-friendly healthy food option: Beyond the binary of GM versus Organic crops.

Journal of biotechnology
Human society cannot afford the luxury of the business-as-usual approach when dealing with the emerging challenges of the 21st century. The challenges of food production to meet the pace of population growth in an environmentally-sustainable manner h...