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Caenorhabditis elegans

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Dynamic Markers for Chaotic Motion in C. elegans.

Nonlinear dynamics, psychology, and life sciences
We describe the locomotion of Caenorhabditis elegans (C. elegans) using nonlinear dynamics. C. elegans is a commonly studied model organism based on ease of maintenance and simple neurological structure. In contrast to traditional microscopic techniq...

Machine learning approach to gene essentiality prediction: a review.

Briefings in bioinformatics
UNLABELLED: Essential genes are critical for the growth and survival of any organism. The machine learning approach complements the experimental methods to minimize the resources required for essentiality assays. Previous studies revealed the need to...

Organizing principles of the C. elegans contactome.

Cell systems
Two recent studies published in Nature generate and analyze, for the first time, the network of ∼100,000 membrane contacts between neurons in the C. elegans nerve ring. These novel data, extracted from legacy electron microscographs, represent a shif...

Toward a living soft microrobot through optogenetic locomotion control of .

Science robotics
Learning from the locomotion of natural organisms is one of the most effective strategies for designing microrobots. However, the development of bioinspired microrobots is still challenging because of technical bottlenecks such as design and seamless...

The Gene Ontology resource: enriching a GOld mine.

Nucleic acids research
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The n...

[Identification of nucleosome positioning using support vector machine method based on comprehensive DNA sequence feature].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
In this article, based on z-curve theory and position weight matrix (PWM), a model for nucleosome sequences was constructed. Nucleosome sequence dataset was transformed into three-dimensional coordinates, PWM of the nucleosome sequences was calculate...

Text mining meets community curation: a newly designed curation platform to improve author experience and participation at WormBase.

Database : the journal of biological databases and curation
Biological knowledgebases rely on expert biocuration of the research literature to maintain up-to-date collections of data organized in machine-readable form. To enter information into knowledgebases, curators need to follow three steps: (i) identify...

LeNup: learning nucleosome positioning from DNA sequences with improved convolutional neural networks.

Bioinformatics (Oxford, England)
MOTIVATION: Nucleosome positioning plays significant roles in proper genome packing and its accessibility to execute transcription regulation. Despite a multitude of nucleosome positioning resources available on line including experimental datasets o...

Genome-wide pre-miRNA discovery from few labeled examples.

Bioinformatics (Oxford, England)
MOTIVATION: Although many machine learning techniques have been proposed for distinguishing miRNA hairpins from other stem-loop sequences, most of the current methods use supervised learning, which requires a very good set of positive and negative ex...