A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of geneti...
Journal of bioinformatics and computational biology
Feb 8, 2015
Protein-RNA interactions (PRIs) are considerably important in a wide variety of cellular processes, ranging from transcriptional and post-transcriptional regulations of gene expression to the active defense of host against virus. With the development...
Early brain connectivity development consists of multiple stages: birth of neurons, their migration and the subsequent growth of axons and dendrites. Each stage occurs within a certain period of time depending on types of neurons and cortical layers....
Journal of the American Chemical Society
Jul 2, 2025
Fluorescence lifetime imaging microscopy (FLIM) is a powerful optical tool widely used in biomedical research to study changes in a sample's microenvironment. However, data collection and interpretation are often challenging, and traditional methods ...
Deep learning label-free cell imaging has become essential in modern medical applications, enabling precise cell analysis while preserving natural biological functions and structures by removing the need for potentially disruptive staining reagents. ...
IEEE journal of biomedical and health informatics
Jun 1, 2025
Predicting interactions between drugs and their targets is vital for drug discovery and repositioning. Conventional techniques are slow and labor-intensive, while deep learning algorithms offer efficient solutions. However, deep learning often focus ...
Non-contact behavioral study through intelligent image analysis is becoming increasingly vital in animal neuroscience and ethology. The shift from traditional "black box" methods to more open and intelligent approaches is driven by advances in deep l...
MOTIVATION: Automated cell lineage tracing throughout embryogenesis plays a key role in the study of regulatory control of cell fate differentiation, morphogenesis and organogenesis in the development of animals, including nematode Caenorhabditis ele...
Studies in health technology and informatics
Nov 23, 2023
Recombinant protein expression is a crucial technique in biology, with E. coli being the most widely used expression system. However, due to growth pressure, the expression of large molecular weight proteins in E. coli has remained a challenging task...
Deep-brain microscopy is strongly limited by the size of the imaging probe, both in terms of achievable resolution and potential trauma due to surgery. Here, we show that a segment of an ultra-thin multi-mode fiber (cannula) can replace the bulky mic...
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