AIMC Topic: Chromatin

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Chromatin accessibility prediction via a hybrid deep convolutional neural network.

Bioinformatics (Oxford, England) Mar 1, 2018
MOTIVATION: A majority of known genetic variants associated with human-inherited diseases lie in non-coding regions that lack adequate interpretation, making it indispensable to systematically discover functional sites at the whole genome level and p...
Humans Neural Networks, Computer Software Genomics Sequence Analysis, DNA Genome, Human Regulatory Sequences, Nucleic Acid Chromatin
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Chromatin accessibility prediction via convolutional long short-term memory networks with k-mer embedding.

Bioinformatics (Oxford, England) Jul 15, 2017
MOTIVATION: Experimental techniques for measuring chromatin accessibility are expensive and time consuming, appealing for the development of computational approaches to predict open chromatin regions from DNA sequences. Along this direction, existing...
Humans Neural Networks, Computer Software Computational Biology Cell Line Chromatin
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HIPred: an integrative approach to predicting haploinsufficient genes.

Bioinformatics (Oxford, England) Jun 15, 2017
MOTIVATION: A major cause of autosomal dominant disease is haploinsufficiency, whereby a single copy of a gene is not sufficient to maintain the normal function of the gene. A large proportion of existing methods for predicting haploinsufficiency inc...
Humans Machine Learning Protein Interaction Maps Genomics Sequence Analysis, RNA Epigenesis, Genetic Sequence Analysis, DNA Genome, Human Histones Chromatin Haploinsufficiency
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LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns.

Oncotarget Nov 24, 2015
Accumulating evidences suggest that long non-coding RNAs (lncRNAs) perform important functions. Genome-wide chromatin-states area rich source of information about cellular state, yielding insights beyond what is typically obtained by transcriptome pr...
Humans Algorithms Cells, Cultured Neoplasms Gene Expression Profiling Cell Line, Tumor Gene Regulatory Networks RNA, Messenger Models, Genetic Hep G2 Cells Cell Line RNA, Long Noncoding HeLa Cells Methylation Promoter Regions, Genetic Lysine K562 Cells Histones Gene Ontology Chromatin Transcription Initiation Site
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