AIMC Topic: Clostridioides difficile

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Organism burden, toxin concentration, and lactoferrin concentration do not distinguish between clinically significant and nonsignificant diarrhea in patients with Clostridium difficile.

Diagnostic microbiology and infectious disease Nov 30, 2015
Clostridium difficile infection is often overdiagnosed in patients with mild diarrhea. We evaluated 4 biomarkers as surrogates for clinically significant diarrhea (≥ 3 episodes in 24 hours) in 59 PCR-positive patients with and 59 PCR-positive patient...
Humans Female Male Middle Aged Severity of Illness Index Case-Control Studies Diarrhea Feces Lactoferrin Bacterial Load Clostridium Infections Bacterial Toxins Clostridioides difficile
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A Deep Learning Approach to Antibiotic Discovery.

Cell Feb 20, 2020
Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed pr...
Machine Learning Anti-Bacterial Agents Animals Drug Discovery Mice Mice, Inbred BALB C Mice, Inbred C57BL Mycobacterium tuberculosis Acinetobacter baumannii Databases, Chemical Clostridioides difficile Small Molecule Libraries Cheminformatics Thiadiazoles
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AI Tackles Hospital Infections: Machine Learning Is Helping Clinicians.

IEEE pulse Jan 1, 2018
For Ashley Zappia (Figure 1), getting her hands dirty was part of her job. Even though she always tried to remain as clean as possible, her work as a nursing aide at a Southern California hospital required a lot of diapering, changing, and other hand...
Humans Machine Learning Risk Factors Infection Control Gastrointestinal Microbiome Immunocompromised Host Medical Informatics Cross Infection Clostridium Infections Clostridioides difficile
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Procalcitonin in inflammatory bowel disease: Drawbacks and opportunities.

World journal of gastroenterology Dec 21, 2017
The measurement of procalcitonin has recently become a mainstay for the diagnosis and therapeutic management of severe bacterial infections, especially those sustained by Gram-negative bacteria. Therefore, the aim of this article is to provide a narr...
Humans Biomarkers Inflammatory Bowel Diseases Severity of Illness Index Bacterial Infections Gastrointestinal Tract Protein Precursors Clostridioides difficile Calcitonin
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