DNA methylation is an epigenetic modification that regulates gene expression by adding methyl groups to DNA, affecting cellular function and disease development. Machine learning, a subset of artificial intelligence, analyzes large datasets to identi...
Recurrent spontaneous abortion (RSA) represents a significant challenge in reproductive obstetrics, affecting approximately 5% of couples globally. Despite various treatments, the effectiveness of these interventions remains highly contentious. Emerg...
Yu Xue is a professor in the College of Life Science and Technology at Huazhong University of Science and Technology, and hold a joint position in the Hubei Hongshan Laboratory at Huazhong Agricultural University. He received two B.E. degrees in poly...
Chronic kidney disease (CKD) can induce chronic heart failure (CHF), a condition referred to as type 4 cardiorenal syndrome (CRS4). The pathophysiological mechanisms remain unclear, and suitable early warning biomarkers for CHF in CKD patients are la...
DeepRNA-Reg employs advances in deep learning to enable high-fidelity comparative analysis of paired datasets of high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP). In a HITS-CLIP experimental paradigm where Ag...
Deep learning for protein function prediction faces significant challenges in identifying disease-specific proteins. We present Extracellular Matrix Protein Predictor (EPOP), an advanced transfer learning framework leveraging protein language models ...
BACKGROUND: Primary Sjögren's syndrome (pSS) is an autoimmune and inflammatory disorder that may affect the lungs, leading to interstitial lung disease (ILD). However, the diagnosis of progression from pSS to ILD is frequently delayed due to unstanda...
BACKGROUND: Single-cell foundation models (scFMs) have emerged as powerful tools for integrating heterogeneous datasets and exploring biological systems. Despite high expectations, their ability to extract unique biological insights beyond standard m...
BACKGROUND: Preeclampsia (PE) is a serious hypertensive complication during pregnancy characterized by immune dysregulation and vascular dysfunction, however, the precise molecular mechanisms and effective therapeutic strategies remain unclear. This ...
Periodontitis, a prevalent inflammatory disease, leads to the progressive destruction of periodontal tissues and poses significant systemic health risks. Despite its widespread impact, the molecular mechanisms driving periodontitis remain poorly unde...
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