AIMC Topic: Computer Simulation

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Fishes Go MOO: Pareto analysis of speed and cost of transport across a 6-dimensional design space.

Bioinspiration & biomimetics
Aquatic organisms exhibit remarkable diversity in swimming strategies, even within shared modes such as body-caudal fin (BCF) propulsion. Here, we investigate the biomechanical underpinnings of BCF swimming by mapping performance trade-offs across a ...

Physics-based surface patch analysis for prediction of hydrophobic contribution to viscosity of mAbs.

mAbs
The viscosity of monoclonal antibody solutions is critical in their biopharmaceutical application, as it directly influences the ease of subcutaneous injection. Although many descriptors have been developed to enable the prediction of viscosity, the...

Prodrug-ML: prodrug-likeness prediction via machine learning on sampled negative decoys.

Journal of computer-aided molecular design
A prodrug is a pharmacologically inactive (or attenuated) derivative that undergoes bioreversible transformation in vivo to release an active parent drug, enabling temporary optimization of properties such as solubility, permeability, and targeting. ...

Assessment of ChatGPT-5 as an Artificial Intelligence Tool for Exploring Emerging Dimensions of Clinical Simulation: A Proof-of-concept Study.

Journal of medical systems
Artificial intelligence (AI) and large language models (LLMs) such as ChatGPT-5 are increasingly applied in medical education. However, their potential role in clinical simulation remains largely unexplored. This descriptive proof-of-concept study ai...

Data-driven queueing modelling: a simulation case study of emergency department crowding.

BMJ health & care informatics
OBJECTIVES: Emergency department crowding refers to a complex state of congestion associated with a set of performance indicators such as occupation levels, waiting times and specific scores. Among current methods to model it, an objective gap exists...

Bridging Model and Experiment in Systems Neuroscience with Cleo: The Closed-Loop, Electrophysiology, and Optophysiology Simulation Testbed.

The Journal of neuroscience : the official journal of the Society for Neuroscience
Systems neuroscience has experienced an explosion of new tools for reading and writing neural activity, enabling exciting new experiments (e.g., all-optical interrogation, closed-loop control) for interrogating neural circuits. Unfortunately, these a...

Evaluation of visual patient predictive for enhancing level 3 situation awareness: protocol for a multicentre randomised computer-based simulation and diagnostic accuracy study (true positive rate, precision, average lead time).

BMJ open
INTRODUCTION: Visual Patient Predictive (VPP) is an AI-based extension of the Visual Patient Avatar (VPA) that integrates deep learning models to predict upcoming vital sign deviations and display them as dashed visual elements. By explicitly showing...

Optimization analysis of a bio-inspired robotic fish employing a crank-linkage propulsion system.

Bioinspiration & biomimetics
Modern bio-inspired robotic fish design increasingly focuses on integrating biological inspiration with engineering-oriented structural solutions to enhance locomotion performance and meet practical application demands. Among these, the crank-linkage...

Virtual parking path planning in narrow roads based on fuzzy pure pursuit algorithm.

PloS one
To address the issues of low adaptability and significant tracking errors in parking scenarios when using fixed look-ahead distance Pure Pursuit (PP) algorithms, this paper proposes an automatic parking path tracking control algorithm based on Fuzzy ...

Adaptive fractional-order non-singular terminal sliding mode control for omnidirectional quadrotors based on WRBF neural network.

PloS one
This paper presents a novel robust six-degree-of-freedom trajectory tracking control strategy for tilt-rotor quadrotors operating under uncertainties and disturbances. The key contribution lies in a unified framework that synergistically co-designs a...