AIMC Topic: Computer Simulation
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Using Emulation to Engineer and Understand Simulations of Biological Systems.
IEEE/ACM transactions on computational biology and bioinformatics
Jun 7, 2018
Modeling and simulation techniques have demonstrated success in studying biological systems. As the drive to better capture biological complexity leads to more sophisticated simulators, it becomes challenging to perform statistical analyses that help...
Modeling asynchronous event sequences with RNNs.
Journal of biomedical informatics
Jun 5, 2018
Sequences of events have often been modeled with computational techniques, but typical preprocessing steps and problem settings do not explicitly address the ramifications of timestamped events. Clinical data, such as is found in electronic health re...
Soft tissue deformation modelling through neural dynamics-based reaction-diffusion mechanics.
Medical & biological engineering & computing
May 30, 2018
Soft tissue deformation modelling forms the basis of development of surgical simulation, surgical planning and robotic-assisted minimally invasive surgery. This paper presents a new methodology for modelling of soft tissue deformation based on reacti...
A portable structural analysis library for reaction networks.
Bio Systems
May 30, 2018
The topology of a reaction network can have a significant influence on the network's dynamical properties. Such influences can include constraints on network flows and concentration changes or more insidiously result in the emergence of feedback loop...
Neuronal network-based mathematical modeling of perceived verticality in acute unilateral vestibular lesions: from nerve to thalamus and cortex.
Journal of neurology
May 29, 2018
Acute unilateral lesions of vestibular graviceptive pathways from the otolith organs and semicircular canals via vestibular nuclei and the thalamus to the parieto-insular vestibular cortex regularly cause deviations of perceived verticality in the fr...
Deep Neural Networks for Modeling Visual Perceptual Learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience
May 23, 2018
Understanding visual perceptual learning (VPL) has become increasingly more challenging as new phenomena are discovered with novel stimuli and training paradigms. Although existing models aid our knowledge of critical aspects of VPL, the connections ...
Multiclassification Prediction of Enzymatic Reactions for Oxidoreductases and Hydrolases Using Reaction Fingerprints and Machine Learning Methods.
Journal of chemical information and modeling
May 21, 2018
Drug metabolism is a complex procedure in the human body, including a series of enzymatically catalyzed reactions. However, it is costly and time consuming to investigate drug metabolism experimentally; computational methods are hence developed to pr...
Optimal two-stage dynamic treatment regimes from a classification perspective with censored survival data.
Biometrics
May 18, 2018
Clinicians often make multiple treatment decisions at key points over the course of a patient's disease. A dynamic treatment regime is a sequence of decision rules, each mapping a patient's observed history to the set of available, feasible treatment...
P Systems-Based Computing Polynomials With Integer Coefficients: Design and Formal Verification.
IEEE transactions on nanobioscience
May 16, 2018
Automatic design of mechanical procedures solving abstract problems is a relevant scientific challenge. In particular, automatic design of membranes systems performing some prefixed tasks is an important and useful research topic in the area of Natur...
Simulation of patient flow in multiple healthcare units using process and data mining techniques for model identification.
Journal of biomedical informatics
May 16, 2018
INTRODUCTION: An approach to building a hybrid simulation of patient flow is introduced with a combination of data-driven methods for automation of model identification. The approach is described with a conceptual framework and basic methods for comb...
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