AI Medical Compendium Topic:
Computer Simulation

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Can We Predict Clinical Pharmacokinetics of Highly Lipophilic Compounds by Integration of Machine Learning or In Vitro Data into Physiologically Based Models? A Feasibility Study Based on 12 Development Compounds.

Molecular pharmaceutics
While high lipophilicity tends to improve potency, its effects on pharmacokinetics (PK) are complex and often unfavorable. To predict clinical PK in early drug discovery, we built human physiologically based PK (PBPK) models integrating either (i) ma...

A guide to systems-level immunomics.

Nature immunology
The immune system is highly complex and distributed throughout an organism, with hundreds to thousands of cell states existing in parallel with diverse molecular pathways interacting in a highly dynamic and coordinated fashion. Although the character...

Predictive Control of the Mobile Robot under the Deep Long-Short Term Memory Neural Network Model.

Computational intelligence and neuroscience
At present, there is a phenomenon of network data packet loss in the trajectory tracking control system, which will degrade or even destabilize the system's performance. Therefore, this work first explains the theory of the deep long-short term memor...

Intelligent Detection and Diagnosis of Power Failure Relying on BP Neural Network Algorithm.

Computational intelligence and neuroscience
The development of economy and the needs of urban planning have led to the rapid growth of power applications and the corresponding frequent occurrence of power failures, which many times lead to a series of economic losses due to failure to repair i...

Ensemble Dilated Convolutional Neural Network and Its Application in Rotating Machinery Fault Diagnosis.

Computational intelligence and neuroscience
Fault diagnosis of rotating machinery is an attractive yet challenging task. This paper presents a novel intelligent fault diagnosis scheme for rotating machinery based on ensemble dilated convolutional neural networks. The novel fault diagnosis fram...

Recursive Minimum-Variance Filter Design for State-Saturated Complex Networks With Uncertain Coupling Strengths Subject to Deception Attacks.

IEEE transactions on cybernetics
In this article, the recursive filtering problem is investigated for state-saturated complex networks (CNs) subject to uncertain coupling strengths (UCSs) and deception attacks. The measurement signals transmitted via the communication network may su...

Asymmetric Input-Output Constraint Control of a Flexible Variable-Length Rotary Crane Arm.

IEEE transactions on cybernetics
This article demonstrates the realization of angle tracking and deformation suppression by developing two boundary controllers for a flexible variable-length rotary crane arm with extraneous disturbances and asymmetric input-output constraints. The d...

Energy-Saving Robust Saturated Control for Active Suspension Systems via Employing Beneficial Nonlinearity and Disturbance.

IEEE transactions on cybernetics
This article proposes a novel control framework for active suspension systems by purposely employing beneficial nonlinearity and a useful disturbance effect for control performance enhancement. To this aim, a novel amplitude-limited PD-SMC control sc...

Input-to-State Stabilization of Stochastic Markovian Jump Systems Under Communication Constraints: Genetic Algorithm-Based Performance Optimization.

IEEE transactions on cybernetics
This work investigates the stabilization problem of uncertain stochastic Markovian jump systems (MJSs) under communication constraints. To reduce the bandwidth usage, a discrete-time Markovian chain is employed to implement the stochastic communicati...

Model-Free Containment Control of Underactuated Surface Vessels Under Switching Topologies Based on Guiding Vector Fields and Data-Driven Neural Predictors.

IEEE transactions on cybernetics
This article investigates the model-free containment control of multiple underactuated unmanned surface vessels (USVs) subject to unknown kinetic models. A novel cooperative control architecture is presented for achieving a containment formation unde...