IEEE/ACM transactions on computational biology and bioinformatics
Aug 8, 2022
Drug combination therapies have been a viable strategy for the treatment of complex diseases such as cancer due to increased efficacy and reduced side effects. However, experimentally validating all possible combinations for synergistic interaction e...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 8, 2022
Epigenetic modifications have a vital role in gene expression and are linked to cellular processes such as differentiation, development, and tumorigenesis. Thus, the availability of reliable and accurate methods for identifying and defining these cha...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 8, 2022
Recently, digital pathology image-based prognosis prediction has become a hot topic in healthcare research to make early decisions on therapy and improve the treatment quality of patients. Therefore, there has been a recent surge of interest in desig...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 8, 2022
The identification of compound-protein relations (CPRs), which includes compound-protein interactions (CPIs) and compound-protein affinities (CPAs), is critical to drug development. A common method for compound-protein relation identification is the ...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 8, 2022
Histopathological identification of tumor tissue is one of the routine pathological diagnoses for pathologists. Recently, computational pathology has been successfully interpreted by a variety of deep learning-based applications. Nevertheless, the hi...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 8, 2022
DNA barcodes with short sequence fragments are used for species identification. Because of advances in sequencing technologies, DNA barcodes have gradually been emphasized. DNA sequences from different organisms are easily and rapidly acquired. There...
PURPOSE: To identify disease activity and effects of intravitreal pegcetacoplan treatment on the topographic progression of geographic atrophy (GA) secondary to age-related macular degeneration quantified in spectral-domain OCT (SD-OCT) by automated ...
Medicine and science in sports and exercise
Aug 6, 2022
PURPOSE: Muscle anatomical cross-sectional area (ACSA) can be assessed using ultrasound and images are usually evaluated manually. Here, we present DeepACSA, a deep learning approach to automatically segment ACSA in panoramic ultrasound images of the...
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Aug 6, 2022
BACKGROUND: Accurate pre-treatment prediction of neoadjuvant chemotherapy (NACT) resistance in patients with locally advanced gastric cancer (LAGC) is essential for timely surgeries and optimized treatments. We aim to evaluate the effectiveness of de...
PURPOSE: To investigate whether the iodine density of liver parenchyma in the equilibrium phase and extracellular volume fraction (ECV) measured by deep learning-based spectral computed tomography (CT) can enable noninvasive liver fibrosis staging.
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