AIMC Topic: Dihydropyridines

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Machine Learning Prediction of Allosteric Drug Activity from Molecular Dynamics.

The journal of physical chemistry letters Apr 12, 2021
Allosteric drugs have been attracting increasing interest over the past few years. In this context, it is common practice to use high-throughput screening for the discovery of non-natural allosteric drugs. While the discovery stage is supported by a ...
Humans Machine Learning Molecular Structure Molecular Dynamics Simulation Biphenyl Compounds Pyrones Coumarins Dihydropyridines Allosteric Regulation
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Effect of Switching from Cilnidipine to Azelnidipine on Cardiac Sympathetic Nerve Function in Patients with Heart Failure Preserved Ejection Fraction.

International heart journal Dec 20, 2017
Cardiac sympathetic nerve activity is known to play a key role in the development and progression of heart failure (HF). Azelnidipine, an L-type calcium channel blocker (CCB), inhibits the sympathetic nerve activity of the central system. In contrast...
Humans Retrospective Studies Female Aged Aged, 80 and over Adult Male Stroke Volume Echocardiography Middle Aged Treatment Outcome Follow-Up Studies Dose-Response Relationship, Drug Heart Heart Failure Drug Substitution Calcium Channel Blockers Radionuclide Imaging Azetidinecarboxylic Acid Dihydropyridines Sympathetic Nervous System
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