BACKGROUND: Robotic systems for chemotherapy preparation offer improved accuracy and staff safety but require substantial capital investment. This study assessed the economic performance of a domestically developed robotic chemotherapy compounding sy...
Direct compression (DC) remains a popular manufacturing technology for producing solid dosage forms. However, the formulation optimisation is a laborious process, costly and time-consuming. The aim of this study was to determine whether machine learn...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Jun 21, 2025
The application of artificial neural networks (ANNs) has the potential to fundamentally change the pharmaceutical industry, making manufacturing more agile, robust, efficient and reliable. Although ANNs' application as data-driven soft sensors has a ...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Jun 11, 2025
Pharmaceutical manufacturing has surged in drug development with the rise of Pharma 4.0, leveraging artificial intelligence (AI) to improve efficiency, optimize resource use, and reduce production times. Direct Tablet Compression (DTC), a key manufac...
International journal of pharmaceutics
Jun 8, 2025
Co-spray drying technology represents an increasingly important approach in preparing dry powder inhalation (DPI) formulations. Compared to conventional spray drying, co-spray drying typically yields particles characterized by improved aerosol perfor...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Apr 29, 2025
In the pharmaceutical manufacturing industry, continuous production methods have been recognised as providing several benefits compared to traditional batch production. These benefits include increased flexibility, higher product output, enhanced qua...
Journal of controlled release : official journal of the Controlled Release Society
Apr 21, 2025
Long-acting injectable (LAI) formulations, which deliver drugs over weeks or months, have been in use for more than three decades. Most clinically approved LAI products are formulated using poly(lactide-co-glycolide) (PLGA) polymers. Historically, th...
PURPOSE: Predicting powder blend flowability is necessary for pharmaceutical manufacturing but challenging and resource-intensive. The purpose was to develop machine learning (ML) models to help predict flowability across multiple flow categories, id...
OBJECTIVE: Amorphous solid dispersion (ASD) is widely utilized to enhance the solubility and bioavailability of water-insoluble drugs. However, conventional experimental approaches for ASD development are often resource-intensive and time-consuming. ...
International journal of pharmaceutics
Feb 15, 2025
We propose a novel approach for predicting the solid fraction after roller compaction processes. It is crucial to predict and control the solid fraction, as it has a significant impact on the product quality. The solid fraction can be theoretically p...
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