AIMC Topic: Drug Development

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The role of artificial intelligence in the development of anticancer therapeutics from natural polyphenols: Current advances and future prospects.

Pharmacological research Aug 30, 2024
Natural polyphenols, abundant in the human diet, are derived from a wide variety of sources. Numerous preclinical studies have demonstrated their significant anticancer properties against various malignancies, making them valuable resources for drug ...
Polyphenols Animals Neoplasms Humans Artificial Intelligence Drug Discovery Antineoplastic Agents Drug Development
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On the Application of Artificial Intelligence/Machine Learning (AI/ML) in Late-Stage Clinical Development.

Therapeutic innovation & regulatory science Aug 21, 2024
Whereas AI/ML methods were considered experimental tools in clinical development for some time, nowadays they are widely available. However, stakeholders in the health care industry still need to answer the question which role these methods can reali...
Machine Learning Drug Development Humans Artificial Intelligence
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Accelerating drug discovery, development, and clinical trials by artificial intelligence.

Med (New York, N.Y.) Aug 21, 2024
Artificial intelligence (AI) has profoundly advanced the field of biomedical research, which also demonstrates transformative capacity for innovation in drug development. This paper aims to deliver a comprehensive analysis of the progress in AI-assis...
Drug Development Clinical Trials as Topic Artificial Intelligence Drug Discovery Humans
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The Artificial Intelligence-Powered New Era in Pharmaceutical Research and Development: A Review.

AAPS PharmSciTech Aug 15, 2024
Currently, artificial intelligence (AI), machine learning (ML), and deep learning (DL) are gaining increased interest in many fields, particularly in pharmaceutical research and development, where they assist in decision-making in complex situations....
Humans Artificial Intelligence Drug Discovery Drug Development Quality Control Machine Learning Precision Medicine Technology, Pharmaceutical Pharmaceutical Research
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Revolutionizing adjuvant development: harnessing AI for next-generation cancer vaccines.

Frontiers in immunology Aug 14, 2024
With the COVID-19 pandemic, the importance of vaccines has been widely recognized and has led to increased research and development efforts. Vaccines also play a crucial role in cancer treatment by activating the immune system to target and destroy c...
Drug Development Adjuvants, Immunologic Cancer Vaccines COVID-19 Animals Vaccine Development Humans SARS-CoV-2 Neoplasms Artificial Intelligence
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Recent progress in artificial intelligence and machine learning for novel diabetes mellitus medications development.

Current medical research and opinion Aug 8, 2024
Diabetes mellitus, stemming from either insulin resistance or inadequate insulin secretion, represents a complex ailment that results in prolonged hyperglycemia and severe complications. Patients endure severe ramifications such as kidney disease, vi...
Humans Artificial Intelligence Drug Development Hypoglycemic Agents Machine Learning Diabetes Mellitus Drug Discovery
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Artificial Intelligence, Drug Development and Frameworks: An Opportunity to Enhance Understanding.

Clinical therapeutics Aug 5, 2024
Drug Development Humans Artificial Intelligence
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Machine Learning Prediction of On/Off Target-driven Clinical Adverse Events.

Pharmaceutical research Aug 2, 2024
OBJECTIVE: Currently, 90% of clinical drug development fails, where 30% of these failures are due to clinical toxicity. The current extensive animal toxicity studies are not predictive of clinical adverse events (AEs) at clinical doses, while current...
Humans Drug-Related Side Effects and Adverse Reactions Animals Machine Learning Drug Development Protein Kinase Inhibitors
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3D printed dosage forms, where are we headed?

Expert opinion on drug delivery Jul 24, 2024
INTRODUCTION: 3D Printing (3DP) is an innovative fabrication technology that has gained enormous popularity through its paradigm shifts in manufacturing in several disciplines, including healthcare. In this past decade, we have witnessed the impact o...
Humans Drug Approval Artificial Intelligence Drug Development Dosage Forms Printing, Three-Dimensional Tablets Pharmaceutical Preparations Precision Medicine Technology, Pharmaceutical Drug Delivery Systems
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Bridging pharmacology and neural networks: A deep dive into neural ordinary differential equations.

CPT: pharmacometrics & systems pharmacology Jul 11, 2024
The advent of machine learning has led to innovative approaches in dealing with clinical data. Among these, Neural Ordinary Differential Equations (Neural ODEs), hybrid models merging mechanistic with deep learning models have shown promise in accura...
Humans Neural Networks, Computer Machine Learning Deep Learning Drug Development Pharmacology, Clinical
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