AIMC Topic: Drug Resistance, Bacterial

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Enhancing Antibiotic Stewardship: A Machine Learning Approach to Predicting Antibiotic Resistance in Inpatient Care.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Antibiotics have been crucial in advancing medical treatments, but the growing threat of antibiotic resistance challenges these achievements and emphasizes the need for innovative stewardship strategies. In this study, we developed machine learning m...

Emulation of a Target Trial to Estimate the Effect of Selective Serotonin Reuptake Inhibitors on the Development of Antimicrobial-Resistant Infections using Electronic Health Record Data and Causal Machine Learning.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Antimicrobial resistance is a significant public health concern. The use of selective serotonin reuptake inhibitors (SSRIs), medications commonly prescribed to treat depression, anxiety, and other psychiatric disorders, is increasing. Previous in vit...

Machine learning-based antibiotic resistance prediction models: An updated systematic review and meta-analysis.

Technology and health care : official journal of the European Society for Engineering and Medicine
BACKGROUND: The widespread use of antibiotics has led to a gradual adaptation of bacteria to these drugs, diminishing the effectiveness of treatments.

Personal Data for Public Benefit: The Regulatory Determinants of Social Licence for Technologically Enhanced Antimicrobial Resistance Surveillance.

Journal of law and medicine
Technologically enhanced surveillance systems have been proposed for the task of monitoring and responding to antimicrobial resistance (AMR) in both human, animal and environmental contexts. The use of these systems is in their infancy, although the ...

Evaluation of Antimicrobial Susceptibility Profile in Salmonella Typhi and Salmonella Paratyphi A: Presenting the Current Scenario in India and Strategy for Future Management.

The Journal of infectious diseases
BACKGROUND: Systematic studies to estimate the disease burden of typhoid and paratyphoid in India are limited. Therefore, a multicenter study on the Surveillance of Enteric Fever in India was carried out to estimate the incidence, clinical presentati...

A machine learning framework to predict antibiotic resistance traits and yet unknown genes underlying resistance to specific antibiotics in bacterial strains.

Briefings in bioinformatics
Recently, the frequency of observing bacterial strains without known genetic components underlying phenotypic resistance to antibiotics has increased. There are several strains of bacteria lacking known resistance genes; however, they demonstrate res...

Deep-ABPpred: identifying antibacterial peptides in protein sequences using bidirectional LSTM with word2vec.

Briefings in bioinformatics
The overuse of antibiotics has led to emergence of antimicrobial resistance, and as a result, antibacterial peptides (ABPs) are receiving significant attention as an alternative. Identification of effective ABPs in lab from natural sources is a cost-...

Prediction of prokaryotic transposases from protein features with machine learning approaches.

Microbial genomics
Identification of prokaryotic transposases (Tnps) not only gives insight into the spread of antibiotic resistance and virulence but the process of DNA movement. This study aimed to develop a classifier for predicting Tnps in bacteria and archaea usin...

Robotic Antimicrobial Susceptibility Platform (RASP): a next-generation approach to One Health surveillance of antimicrobial resistance.

The Journal of antimicrobial chemotherapy
BACKGROUND: Surveillance of antimicrobial resistance (AMR) is critical to reducing its wide-reaching impact. Its reliance on sample size invites solutions to longstanding constraints regarding scalability. A robotic platform (RASP) was developed for ...

An explainable machine learning platform for pyrazinamide resistance prediction and genetic feature identification of Mycobacterium tuberculosis.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Tuberculosis is the leading cause of death from a single infectious agent. The emergence of antimicrobial resistant Mycobacterium tuberculosis strains makes the problem more severe. Pyrazinamide (PZA) is an important component for short-co...