AIMC Topic: Drug Resistance, Microbial
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Using computers to ESKAPE the antibiotic resistance crisis.
Drug discovery today
Oct 21, 2021
Since the discovery of penicillin, the development and use of antibiotics have promoted safe and effective control of bacterial infections. However, the number of antibiotic-resistance cases has been ever increasing over time. Thus, the drug discover...
Combining genetic algorithm with machine learning strategies for designing potent antimicrobial peptides.
BMC bioinformatics
May 11, 2021
BACKGROUND: Current methods in machine learning provide approaches for solving challenging, multiple constraint design problems. While deep learning and related neural networking methods have state-of-the-art performance, their vulnerability in decis...
Prediction of antibiotic-resistance genes occurrence at a recreational beach with deep learning models.
Water research
Mar 3, 2021
Antibiotic resistance genes (ARGs) have been reported to threaten the public health of beachgoers worldwide. Although ARG monitoring and beach guidelines are necessary, substantial efforts are required for ARG sampling and analysis. Accordingly, in t...
AI-based mobile application to fight antibiotic resistance.
Nature communications
Feb 19, 2021
Antimicrobial resistance is a major global health threat and its development is promoted by antibiotic misuse. While disk diffusion antibiotic susceptibility testing (AST, also called antibiogram) is broadly used to test for antibiotic resistance in ...
HMD-ARG: hierarchical multi-task deep learning for annotating antibiotic resistance genes.
Microbiome
Feb 8, 2021
BACKGROUND: The spread of antibiotic resistance has become one of the most urgent threats to global health, which is estimated to cause 700,000 deaths each year globally. Its surrogates, antibiotic resistance genes (ARGs), are highly transmittable be...
Temporal variation and sharing of antibiotic resistance genes between water and wild fish gut in a peri-urban river.
Journal of environmental sciences (China)
Oct 24, 2020
Antibiotic resistance genes (ARGs) as emergence contaminations have spread widely in the water environment. Wild fish may be recipients and communicators of ARGs in the water environment, however, the distribution and transmission of ARGs in the wild...
Feature selection based multivariate time series forecasting: An application to antibiotic resistance outbreaks prediction.
Artificial intelligence in medicine
Feb 19, 2020
Antimicrobial resistance has become one of the most important health problems and global action plans have been proposed globally. Prevention plays a key role in these actions plan and, in this context, we propose the use of Artificial Intelligence, ...
VAMPr: VAriant Mapping and Prediction of antibiotic resistance via explainable features and machine learning.
PLoS computational biology
Jan 13, 2020
Antimicrobial resistance (AMR) is an increasing threat to public health. Current methods of determining AMR rely on inefficient phenotypic approaches, and there remains incomplete understanding of AMR mechanisms for many pathogen-antimicrobial combin...
Fate of pirlimycin and antibiotic resistance genes in dairy manure slurries in response to temperature and pH adjustment.
The Science of the total environment
Dec 26, 2019
Quantifying the fate of antibiotics and antibiotic resistance genes (ARGs) in response to physicochemical factors during storage of manure slurries will aid in efforts to reduce the spread of resistance when manure is land-applied. The objectives of ...
Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology.
PloS one
Nov 19, 2019
Growth in open-source hardware designs combined with the low-cost of high performance optoelectronic and robotics components has supported a resurgence of in-house custom lab equipment development. We describe a low cost (below $700), open-source, fu...
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