AIMC Topic: Drug Therapy

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Enhancing Seasonal Influenza Surveillance: Topic Analysis of Widely Used Medicinal Drugs Using Twitter Data.

Journal of medical Internet research
BACKGROUND: Uptake of medicinal drugs (preventive or treatment) is among the approaches used to control disease outbreaks, and therefore, it is of vital importance to be aware of the counts or frequencies of most commonly used drugs and trending topi...

Network mirroring for drug repositioning.

BMC medical informatics and decision making
BACKGROUND: Although drug discoveries can provide meaningful insights and significant enhancements in pharmaceutical field, the longevity and cost that it takes can be extensive where the success rate is low. In order to circumvent the problem, there...

Learning disease relationships from clinical drug trials.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Our objective is to test the limits of the assumption that better learning from data in medicine requires more granular data. We hypothesize that clinical trial metadata contains latent scientific, clinical, and regulatory expert knowledge...

Magnetic nanoparticles and nanocomposites for remote controlled therapies.

Journal of controlled release : official journal of the Controlled Release Society
This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of M...

Clinical Documents Clustering Based on Medication/Symptom Names Using Multi-View Nonnegative Matrix Factorization.

IEEE transactions on nanobioscience
Clinical documents are rich free-text data sources containing valuable medication and symptom information, which have a great potential to improve health care. In this paper, we build an integrating system for extracting medication names and symptom ...

MCD-LightGBM System for Intelligent Analyzing Heterogeneous Clinical Drug Therapeutic Effects.

IEEE journal of biomedical and health informatics
Causal effect estimation of individual heterogeneity is a core issue in the field of causal inference, and its application in medicine poses an active and challenging problem. In high-risk decision-making domain such as healthcare, inappropriate trea...

Building longitudinal medication dose data using medication information extracted from clinical notes in electronic health records.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: To develop an algorithm for building longitudinal medication dose datasets using information extracted from clinical notes in electronic health records (EHRs).

medExtractR: A targeted, customizable approach to medication extraction from electronic health records.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: We developed medExtractR, a natural language processing system to extract medication information from clinical notes. Using a targeted approach, medExtractR focuses on individual drugs to facilitate creation of medication-specific research...

Learning to detect and understand drug discontinuation events from clinical narratives.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Identifying drug discontinuation (DDC) events and understanding their reasons are important for medication management and drug safety surveillance. Structured data resources are often incomplete and lack reason information. In this article...

The Application of Machine Learning Techniques in Clinical Drug Therapy.

Current computer-aided drug design
INTRODUCTION: The development of a novel drug is an extremely complicated process that includes the target identification, design and manufacture, and proper therapy of the novel drug, as well as drug dose selection, drug efficacy evaluation, and adv...