AIMC Topic: fms-Like Tyrosine Kinase 3

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Classification of FLT3 inhibitors and SAR analysis by machine learning methods.

Molecular diversity May 5, 2023
FMS-like tyrosine kinase 3 (FLT3) is a type III receptor tyrosine kinase, which is an important target for anti-cancer therapy. In this work, we conducted a structure-activity relationship (SAR) study on 3867 FLT3 inhibitors we collected. MACCS finge...
Humans Neural Networks, Computer Machine Learning Algorithms Support Vector Machine Structure-Activity Relationship Protein Kinase Inhibitors fms-Like Tyrosine Kinase 3
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Clinical insights into hematologic malignancies and comparative analysis of molecular signatures of acute myeloid leukemia in different ethnicities using an artificial intelligence offering.

Medicine Dec 23, 2021
Next generation sequencing generates copious amounts of genomics data, causing manual interpretation to be laborious and non-scalable while remaining subjective (even for highly trained specialists). We evaluated the performance of the artificial int...
Humans Artificial Intelligence Prognosis Republic of Korea Female Aged Aged, 80 and over Young Adult Adult Hematologic Neoplasms Leukemia, Myeloid, Acute Male Middle Aged Adolescent Protein-Tyrosine Kinases Mutation Pharmaceutical Preparations Ethnicity Off-Label Use fms-Like Tyrosine Kinase 3
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Proteomics Analysis of FLT3-ITD Mutation in Acute Myeloid Leukemia Using Deep Learning Neural Network.

Annals of clinical and laboratory science Jan 1, 2019
Deep Learning can significantly benefit cancer proteomics and genomics. In this study, we attempted to determine a set of critical proteins that were associated with the FLT3-ITD mutation in newly-diagnosed acute myeloid leukemia patients. A Deep Lea...
Humans Neural Networks, Computer Leukemia, Myeloid, Acute Deep Learning Proteomics Proteome Blood Proteins Mutation Tandem Repeat Sequences fms-Like Tyrosine Kinase 3
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