AIMC Topic: Focal Adhesion Kinase 1

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SPP1 as a key modulator of M2 macrophage polarization promotes endometriosis progression via activation of the FAK/PI3K/AKT pathway: A bioinformatics and experimental study.

International immunopharmacology Sep 17, 2025
Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially expressed genes, and appl...
Humans Macrophages Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt Cell Movement Macrophage Activation Focal Adhesion Kinase 1 Osteopontin Endometriosis Cell Proliferation Endometrium Signal Transduction Disease Progression Computational Biology Female
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Immunophenotyping identifies key immune biomarkers for coronary artery disease through machine learning.

PloS one Aug 26, 2025
INTRODUCTION: The differences among immune subtypes in coronary artery disease (CAD), their interrelationships, and the associated immune biomarkers remain incompletely understood.
Coronary Artery Disease Gene Ontology Immunophenotyping Focal Adhesion Kinase 1 Machine Learning B7-H1 Antigen Biomarkers Humans
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Discovery and characterization of novel FAK inhibitors for breast cancer therapy via hybrid virtual screening, biological evaluation and molecular dynamics simulations.

Bioorganic chemistry Mar 26, 2025
Focal adhesion kinase (FAK) is a critical drug target implicated in various disease pathways, including hematological malignancies and breast cancer. Therefore, identifying FAK inhibitors with novel scaffolds could offer new opportunities for develop...
Focal Adhesion Protein-Tyrosine Kinases Focal Adhesion Kinase 1 Drug Discovery Cell Proliferation Antineoplastic Agents Breast Neoplasms Molecular Docking Simulation Female Molecular Dynamics Simulation Molecular Structure Protein Kinase Inhibitors Drug Evaluation, Preclinical Humans Dose-Response Relationship, Drug Structure-Activity Relationship Drug Screening Assays, Antitumor
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A machine learning pipeline revealing heterogeneous responses to drug perturbations on vascular smooth muscle cell spheroid morphology and formation.

Scientific reports Dec 2, 2021
Machine learning approaches have shown great promise in biology and medicine discovering hidden information to further understand complex biological and pathological processes. In this study, we developed a deep learning-based machine learning algori...
cdc42 GTP-Binding Protein Focal Adhesion Kinase 1 Vascular System Injuries rac GTP-Binding Proteins Neointima Atherosclerosis Machine Learning Humans Cells, Cultured Muscle, Smooth, Vascular Spheroids, Cellular
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