AIMC Topic: Muscle, Smooth, Vascular

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Genome wide DNA methylation and transcriptome integration analysis reveals potential markers in type A aortic dissection pathogenesis.

Scientific reports Nov 27, 2025
Type A aortic dissection (TAAD) is a vascular disease with high mortality; however, the role of gene methylation in its pathogenesis has received little attention. This study aimed to identify candidate markers of TAAD by integrating methylation and ...
Humans Gene Expression Profiling Transcriptome Cell Proliferation Cell Movement Biomarkers Female Male Middle Aged Aortic Dissection DNA Methylation Muscle, Smooth, Vascular Myocytes, Smooth Muscle
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Detection of aging-induced vascular remodeling based on Raman imaging and deep learning.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Aug 15, 2025
Vascular aging-related remodeling is a common pathological basis for many chronic diseases, so early detection of physical arterial aging is important for their prevention and control. Existing staining methods can only analyze a limited number of ti...
Animals Male Aging Muscle, Smooth, Vascular Collagen Deep Learning Vascular Remodeling Mice Aorta Spectrum Analysis, Raman Mice, Inbred C57BL
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Identification of key genes and biological pathways associated with vascular aging in diabetes based on bioinformatics and machine learning.

Aging May 27, 2024
Vascular aging exacerbates diabetes-associated vascular damage, a major cause of microvascular and macrovascular complications. This study aimed to elucidate key genes and pathways underlying vascular aging in diabetes using integrated bioinformatics...
Diabetes Mellitus Cellular Senescence Muscle, Smooth, Vascular Aging Computational Biology Signal Transduction Humans Machine Learning
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Mechanism of cytotoxicity induced by the cigarette smoke extract (CSE) of heated tobacco products in vascular smooth muscle cells: A comparative study of the cytotoxic effects of CSE and the ferroptosis inducer, erastin.

Journal of pharmacological sciences Dec 27, 2023
Heated tobacco products (HTPs) are marketed worldwide as less harmful alternatives to combustible cigarettes; however, their cytotoxic mechanisms in vascular smooth muscle cells are poorly understood. Ferroptosis is defined as iron-dependent cell dea...
Piperazines Antineoplastic Agents Cigarette Smoking Ferroptosis Muscle, Smooth, Vascular Iron Tobacco Products
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A machine learning pipeline revealing heterogeneous responses to drug perturbations on vascular smooth muscle cell spheroid morphology and formation.

Scientific reports Dec 2, 2021
Machine learning approaches have shown great promise in biology and medicine discovering hidden information to further understand complex biological and pathological processes. In this study, we developed a deep learning-based machine learning algori...
Spheroids, Cellular Vascular System Injuries cdc42 GTP-Binding Protein Focal Adhesion Kinase 1 Neointima rac GTP-Binding Proteins Machine Learning Cells, Cultured Atherosclerosis Muscle, Smooth, Vascular Humans
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Influence of Nanosilver on Endothelial Function and Vascular Reactivity of Isolated Rabbit Carotid Artery.

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria Dec 30, 2018
There is paucity of information on the effects and mechanism of action of Nanosilver on vascular tone andendothelial function in spite of the upsurge in nanotechnology application in biomedicine. The present study determined theeffect of Nanosilver o...
Phenylephrine Vasodilator Agents Animals Endothelium, Vascular Muscle, Smooth, Vascular Silver Muscle Contraction Rabbits Acetylcholine NG-Nitroarginine Methyl Ester Carotid Arteries Carotid Artery, Common
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Differential Kolaviron Attenuated Contractile Responses to Agonists on Isolated Rabbit Aorta in Na+-K+ Pump Blockade.

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria Dec 30, 2017
The mechanism of kolaviron-induced vascular smooth muscles (VSMs) responses has not been fullycharacterised. The present study investigated the effect and mode of action of kolaviron a biflavanoid-complex and majorcomponent of Garcinia Kola-fraction ...
Animals Flavonoids Muscle Contraction Rabbits Aorta Muscle, Smooth, Vascular Garcinia kola Calcium Isometric Contraction Endothelium, Vascular
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G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

Journal of vascular research Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
rho-Associated Kinases rhoA GTP-Binding Protein Muscle, Smooth, Vascular Thiazolidines Hydrazones Thiourea HEK293 Cells Myocytes, Smooth Muscle Signal Transduction Cell Movement Dose-Response Relationship, Drug Receptors, G-Protein-Coupled Humans Time Factors Cell Proliferation Endothelial Cells Naphthols Actin Cytoskeleton Purinones Aminosalicylic Acids Saphenous Vein
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Dissecting Shared Genetic Architecture of Thoracic Aortic Aneurysm and Aortic Related Traits and Identifying SplA/Ryanodine Receptor Domain and SOCS Box Containing 1 Involved in Smooth Muscle Phenotype Switching and Cell Senescence Through Alternative Splicing.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov 30, 2025
Machine learning was employed to annotate images of the thoracic aorta, resulting in the identification of additional thoracic-related targets. However, genetic evaluation of the associations among thoracic aortic traits and their shared genes is lac...
Suppressor of Cytokine Signaling Proteins Animals Male Myocytes, Smooth Muscle Genome-Wide Association Study Aortic Aneurysm, Thoracic Mice Alternative Splicing Mice, Inbred C57BL Cellular Senescence Muscle, Smooth, Vascular Aorta, Thoracic Humans Phenotype Female
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Machine learning powered tools for automated analysis of muscle sympathetic nerve activity recordings.

Physiological reports Aug 1, 2021
Automated analysis and quantification of physiological signals in clinical practice and medical research can reduce manual labor, increase efficiency, and provide more objective, reproducible results. To build a novel platform for the analysis of mus...
Neural Conduction Electrodiagnosis Machine Learning Aged Adult Middle Aged Adolescent Muscle, Smooth, Vascular Signal-To-Noise Ratio Humans Sympathetic Nervous System
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