Alzheimer's disease (AD) is a prevalent neurodegenerative disease that primarily affects the elderly population. The early detection of mild cognitive impairment (MCI) holds significant clinical importance for prompt intervention and treatment of AD....
Interdisciplinary sciences, computational life sciences
Jun 2, 2025
Non-coding RNAs (ncRNAs) are one of the components of epigenetic mechanisms that regulates gene expression. Studying ncRNA-protein interactions (NPI) can help to explore a wide range of biological features and related diseases. Traditional NPI resear...
IEEE journal of biomedical and health informatics
May 6, 2025
The multi-modal neuroimage study has provided insights into understanding the heteromodal relationships between brain network organization and behavioral phenotypes. Integrating data from various modalities facilitates the characterization of the int...
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
May 2, 2025
The development of high throughput technologies has resulted in the collection of large quantities of genomic and transcriptomic data. However, identifying disease-associated genes or networks from these data has remained an ongoing challenge. In rec...
IEEE transactions on neural networks and learning systems
May 2, 2025
Due to the absence of a gold standard for threshold selection, brain networks constructed with inappropriate thresholds risk topological degradation or contain noise connections. Therefore, graph neural networks (GNNs) exhibit weak robustness and ove...
IEEE transactions on neural networks and learning systems
May 2, 2025
Reconstructing gene regulatory networks (GRNs) using single-cell RNA sequencing (scRNA-seq) data holds great promise for unraveling cellular fate development and heterogeneity. While numerous machine-learning methods have been proposed to infer GRNs ...
The CRISPR-Cas system, an adaptive immune mechanism found in bacteria and archaea, has evolved into a promising genomic editing tool, with various types of Cas proteins playing a crucial role. In this study, we developed a set of strategies for minin...
Anesthesia plays a pivotal role in modern surgery by facilitating controlled states of unconsciousness. Precise control is crucial for safe and pain-free surgeries. Monitoring anesthesia depth accurately is essential to guide anesthesiologists, optim...
Computer methods in biomechanics and biomedical engineering
Apr 24, 2025
Fetal electrocardiogram (ECG) provides a non-invasive means to assess fetal heart health, but isolating the fetal signal from the dominant maternal ECG remains challenging. This study introduces the FHH-AMGNN-HTSOA-ECG-AD method for enhanced fetal ar...
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Apr 16, 2025
The coordination of muscles in human locomotion is commonly understood as the integration of motor modules known as muscle synergies. Recent research has delved into the adaptation of muscle synergies during the acquisition of new motor skills. Howev...
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