AIMC Topic: Histocompatibility Testing

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Cross-organ hierarchy of HLA molecular mismatches in donor-specific antibody development in solid organ transplantations.

Cell reports. Medicine May 30, 2025
Donor-specific antibodies (DSAs) against human leukocyte antigen (HLA) play a crucial role in antibody-mediated rejection, a major barrier to successful organ transplantation. Donor-recipient HLA molecular incompatibility critically influences DSA su...
Middle Aged Tissue Donors T-Lymphocytes Male HLA Antigens Isoantibodies Histocompatibility Testing Graft Rejection Organ Transplantation Humans Female
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Machine learning enhanced immunologic risk assessments for solid organ transplantation.

Scientific reports Mar 7, 2025
The purpose of this study was to enhance the prediction of solid-organ recipient and donor crossmatch compatibility by applying machine learning (ML). Prediction of crossmatch compatibility is complex and requires an understanding of the recipient an...
Machine Learning Risk Assessment Humans Alleles Histocompatibility Testing Organ Transplantation HLA Antigens ROC Curve Tissue Donors
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Improved artificial intelligence discrimination of minor histological populations by supplementing with color-adjusted images.

Scientific reports Nov 4, 2023
Despite the dedicated research of artificial intelligence (AI) for pathological images, the construction of AI applicable to histopathological tissue subtypes, is limited by insufficient dataset collection owing to disease infrequency. Here, we prese...
Caffeine Frozen Sections Artificial Intelligence Hospitals Histocompatibility Testing
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Statistical methods versus machine learning techniques for donor-recipient matching in liver transplantation.

PloS one May 21, 2021
Donor-Recipient (D-R) matching is one of the main challenges to be fulfilled nowadays. Due to the increasing number of recipients and the small amount of donors in liver transplantation, the allocation method is crucial. In this paper, to establish a...
Liver Transplantation Transplant Recipients Tissue and Organ Procurement Histocompatibility Testing Data Interpretation, Statistical Bayes Theorem Logistic Models Support Vector Machine Databases, Factual Tissue Donors Humans
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Patterns of 1,748 Unique Human Alloimmune Responses Seen by Simple Machine Learning Algorithms.

Frontiers in immunology Jul 28, 2020
Allele specific antibody response against the polymorphic system of HLA is the allogeneic response marker determining the immunological risk for graft acceptance before and after organ transplantation and therefore routinely studied during the patien...
Histocompatibility Testing Isoantigens Isoantibodies Histocompatibility Immunosuppressive Agents Principal Component Analysis Treatment Outcome Adult Cluster Analysis Male HLA Antigens Middle Aged Pattern Recognition, Automated Graft Survival Graft Rejection Kidney Transplantation Flow Cytometry Female Humans Machine Learning
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Extracting Structured Genotype Information from Free-Text HLA Reports Using a Rule-Based Approach.

Journal of Korean medical science Mar 30, 2020
BACKGROUND: Human leukocyte antigen (HLA) typing is important for transplant patients to prevent a severe mismatch reaction, and the result can also support the diagnosis of various disease or prediction of drug side effects. However, such secondary ...
Data Warehousing Histocompatibility Testing Information Storage and Retrieval Seoul Natural Language Processing HLA Antigens Humans Algorithms Electronic Health Records Genotype
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