AIMC Topic: Isoantibodies
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Cross-organ hierarchy of HLA molecular mismatches in donor-specific antibody development in solid organ transplantations.
Cell reports. Medicine
May 30, 2025
Donor-specific antibodies (DSAs) against human leukocyte antigen (HLA) play a crucial role in antibody-mediated rejection, a major barrier to successful organ transplantation. Donor-recipient HLA molecular incompatibility critically influences DSA su...
Patterns of 1,748 Unique Human Alloimmune Responses Seen by Simple Machine Learning Algorithms.
Frontiers in immunology
Jul 28, 2020
Allele specific antibody response against the polymorphic system of HLA is the allogeneic response marker determining the immunological risk for graft acceptance before and after organ transplantation and therefore routinely studied during the patien...
Treatment Outcome
Cluster Analysis
Middle Aged
Graft Survival
Graft Rejection
Flow Cytometry
Immunosuppressive Agents
Principal Component Analysis
Kidney Transplantation
Female
Adult
Male
Humans
Machine Learning
HLA Antigens
Histocompatibility Testing
Pattern Recognition, Automated
Isoantibodies
Isoantigens
Histocompatibility
Generating automated kidney transplant biopsy reports combining molecular measurements with ensembles of machine learning classifiers.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Apr 10, 2019
We previously reported a system for assessing rejection in kidney transplant biopsies using microarray-based gene expression data, the Molecular Microscope Diagnostic System (MMDx). The present study was designed to optimize the accuracy and stabilit...
High soluble CD30 levels and associated anti-HLA antibodies in patients with failed renal allografts.
The International journal of artificial organs
Dec 26, 2016
INTRODUCTION: Serum soluble CD30 (sCD30), a 120-kD glycoprotein that belongs to the tumor necrosis factor receptor family, has been suggested as a marker of rejection in kidney transplant patients. The aim of this study was to evaluate the relationsh...
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