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Isoantibodies

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High soluble CD30 levels and associated anti-HLA antibodies in patients with failed renal allografts.

The International journal of artificial organs
INTRODUCTION: Serum soluble CD30 (sCD30), a 120-kD glycoprotein that belongs to the tumor necrosis factor receptor family, has been suggested as a marker of rejection in kidney transplant patients. The aim of this study was to evaluate the relationsh...

Generating automated kidney transplant biopsy reports combining molecular measurements with ensembles of machine learning classifiers.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
We previously reported a system for assessing rejection in kidney transplant biopsies using microarray-based gene expression data, the Molecular Microscope Diagnostic System (MMDx). The present study was designed to optimize the accuracy and stabilit...

Patterns of 1,748 Unique Human Alloimmune Responses Seen by Simple Machine Learning Algorithms.

Frontiers in immunology
Allele specific antibody response against the polymorphic system of HLA is the allogeneic response marker determining the immunological risk for graft acceptance before and after organ transplantation and therefore routinely studied during the patien...