BACKGROUND: The aim of this study was to determine if levetiracetam (LEV) is neuroprotective in neonatal rats with hypoxic-ischemic brain injury (HIBI).
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
26737513
There exists a 6-8 hour window of opportunity for the treatment of perinatal Hypoxic-Ischemic Encephalopathy (HIE) following the original insult after which significant irreversible brain injury manifests leading to debilitating neurological conditio...
BACKGROUND: The continuation of life-sustaining therapy in critical care patients with anoxic-ischemic disorders of consciousness (AI-DOC) depends on prognostic tests such as serum neuron-specific enolase (NSE) concentration levels.
Hypoxic-ischemic (HI) studies in preterms lack reliable prognostic biomarkers for diagnostic tests of HI encephalopathy (HIE). Our group's observations from fetal sheep models suggest that potential biomarkers of HIE in the form of developing HI mic...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
31946252
We have recently demonstrated that micro-scale Sharp waves in the first few hours EEG of asphyxiated preterm fetal sheep models are the reliable prognostic biomarkers for Hypoxic-Ischemic Encephalopathy (HIE). Higher number of sharp waves within the ...
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
31419742
OBJECTIVE: Electroencephalogram (EEG) reactivity is a robust predictor of neurological recovery after cardiac arrest, however interrater-agreement among electroencephalographers is limited. We sought to evaluate the performance of machine learning me...
BACKGROUND: Secondary and retrospective use of hospital-hosted clinical data provides a time- and cost-efficient alternative to prospective clinical trials for biomarker development. This study aims to create a retrospective clinical dataset of Magne...
Premature babies are at high risk of serious neurodevelopmental disabilities, which in many cases are related to perinatal hypoxic-ischemic encephalopathy (HIE). Studies of neuroprotection in animal models consistently suggest that treatment must be ...
American journal of obstetrics and gynecology
33098815
An increasing number of delivering women experience major morbidity and mortality. Limited work has been done on automated predictive models that could be used for prevention. Using only routinely collected obstetrical data, this study aimed to devel...