AIMC Topic: Immunotherapy, Adoptive
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CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia.
Cancer letters
May 31, 2022
T cell acute lymphoblastic leukemia (T-ALL) is invasive and heterogeneous, and existing therapies are sometimes unsuccessful. Chimeric antigen receptor (CAR) T cell therapy is a breakthrough tumor treatment method, particularly for B cell acute lymph...
Machine learning-based cytokine microarray digital immunoassay analysis.
Biosensors & bioelectronics
Feb 20, 2021
Serial measurement of a large panel of protein biomarkers near the bedside could provide a promising pathway to transform the critical care of acutely ill patients. However, attaining the combination of high sensitivity and multiplexity with a short ...
Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects.
Ageing research reviews
Jul 1, 2025
Cellular senescence is a complex biological process with a dual role in tissue homeostasis and aging-related pathologies. Accumulation of senescent cells promotes chronic inflammation, tissue dysfunction, age-related diseases, and tumor suppression. ...
Advancing CAR T-cell Therapies with Artificial Intelligence: Opportunities and Challenges.
Blood cancer discovery
May 5, 2025
Artificial intelligence could enhance chimeric antigen receptor T-cell therapy outcomes through optimization of all steps, from target identification, vector design, and manufacturing to personalized data-driven clinical decisions. In this report, we...
New tools for MHC research from machine learning and predictive algorithms to the tumour immunopeptidome.
Immunology
Jul 1, 2018
At a time when immunology seeks to progress ever more rapidly from characterization of a microbial or tumour antigen to the immune correlates that may define protective T-cell immunity, there is a need for robust tools to enable accurate predictions ...
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