AIMC Topic: Knowledge Bases
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Medication-indication knowledge bases: a systematic review and critical appraisal.
Journal of the American Medical Informatics Association : JAMIA
Sep 2, 2015
OBJECTIVE: Medication-indication information is a key part of the information needed for providing decision support for and promoting appropriate use of medications. However, this information is not readily available to end users, and a lot of the re...
Knowledge-Based Query Construction Using the CDSS Knowledge Base for Efficient Evidence Retrieval.
Sensors (Basel, Switzerland)
Aug 28, 2015
Finding appropriate evidence to support clinical practices is always challenging, and the construction of a query to retrieve such evidence is a fundamental step. Typically, evidence is found using manual or semi-automatic methods, which are time-con...
GARN: Sampling RNA 3D Structure Space with Game Theory and Knowledge-Based Scoring Strategies.
PloS one
Aug 27, 2015
Cellular processes involve large numbers of RNA molecules. The functions of these RNA molecules and their binding to molecular machines are highly dependent on their 3D structures. One of the key challenges in RNA structure prediction and modeling is...
Network fingerprint: a knowledge-based characterization of biomedical networks.
Scientific reports
Aug 26, 2015
It can be difficult for biomedical researchers to understand complex molecular networks due to their unfamiliarity with the mathematical concepts employed. To represent molecular networks with clear meanings and familiar forms for biomedical research...
How to build up the actionable knowledge base: the role of 'best fit' framework synthesis for studies of improvement in healthcare.
BMJ quality & safety
Aug 25, 2015
Increasing recognition of the role and value of theory in improvement work in healthcare offers the prospect of capitalising upon, and consolidating, actionable lessons from synthesis of improvement projects and initiatives. We propose that informed ...
Practical Guidelines for Incorporating Knowledge-Based and Data-Driven Strategies into the Inference of Gene Regulatory Networks.
IEEE/ACM transactions on computational biology and bioinformatics
Aug 20, 2015
Modeling gene regulatory networks (GRNs) is essential for conceptualizing how genes are expressed and how they influence each other. Typically, a reverse engineering approach is employed; this strategy is effective in reproducing possible fitting mod...
Participatory approach to the development of a knowledge base for problem-solving in diabetes self-management.
International journal of medical informatics
Aug 8, 2015
OBJECTIVE: To develop an expandable knowledge base of reusable knowledge related to self-management of diabetes that can be used as a foundation for patient-centric decision support tools.
Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysis.
Arthritis research & therapy
Aug 8, 2015
INTRODUCTION: Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. Gene variants directly affect the normal processes of a series of physiological and biochemical reactions, and therefore cause a variety of diseases...
Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.
PLoS computational biology
Aug 7, 2015
Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events. In a typical phosphoproteomics study, phos...
Using distant supervised learning to identify protein subcellular localizations from full-text scientific articles.
Journal of biomedical informatics
Jul 26, 2015
Databases of curated biomedical knowledge, such as the protein-locations reflected in the UniProtKB database, provide an accurate and useful resource to researchers and decision makers. Our goal is to augment the manual efforts currently used to cura...
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