BMC medical informatics and decision making
Oct 14, 2025
BACKGROUND: Leishmaniasis, a neglected tropical disease caused by Leishmania protozoan parasites and transmitted by sandflies, poses a significant global health challenge, especially in resource-limited environments. The life cycle of the parasite in...
Investigating the molecular differences between procyclic (non-infective) and metacyclic (infective) promastigotes is essential for understanding the Leishmania life cycle in the sandfly vector and may aid in identifying molecular markers specific to...
Cutaneous leishmaniasis is a parasitic disease that poses significant diagnostic challenges due to the variability of results and reliance on operator expertise. This study addresses the development of a system based on machine learning algorithms to...
Leishmaniasis, a neglected tropical disease caused by various Leishmania species, poses a significant global health challenge, especially in resource-limited regions. Visceral Leishmaniasis (VL) stands out among its severe manifestations, and current...
Frontiers in cellular and infection microbiology
Sep 26, 2024
Drug repurposing is a promising approach towards the discovery of novel treatments against Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing both costs and duration of the drug discovery process. In previous wor...
Molecular and biochemical parasitology
Aug 22, 2024
The Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host, promastigotes are engulfed by phagocytes (i.e., neutrophils, dendritic cells, and macrophages)...
BACKGROUND: Leishmaniasis is a vector-born neglected parasitic disease belonging to the genus Leishmania. Out of the 30 Leishmania species, 21 species cause human infection that affect the skin and the internal organs. Around, 700,000 to 1,000,000 of...
BACKGROUND: Leishmaniasis, an illness caused by protozoa, accounts for a substantial number of human fatalities globally, thereby emerging as one of the most fatal parasitic diseases. The conventional methods employed for detecting the Leishmania par...
, a single-cell parasite prevalent in tropical and subtropical regions worldwide, can cause varying degrees of leishmaniasis, ranging from self-limiting skin lesions to potentially fatal visceral complications. As such, the parasite has been the subj...
Bioorganic & medicinal chemistry letters
Dec 24, 2015
In present work we have designed and synthesized total twelve novel 3-(3-(1H-indol-3-yl)-3-phenylpropanoyl)-4-hydroxy-2H-chromen-2-one derivatives 13(a-l) using Ho(3+) doped CoFe2O4 nanoparticles as catalyst and evaluated for their potential antileis...
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